Association Study On ADAM33Polymorphisms In Allergic Rhinitis In A Chinese Han Population

Background: The ADAM33gene has been identified as a potentially importantasthma candidate gene and polymorphisms in this gene have been shown to beassociated with asthma and seasonal allergic rhinitis.Objective: To assess whether the ADAM33polymorphisms are associated withpersistent allergic rhinitis (PER) due to house dust mites in a Chinese population.Methods: In a hospital-based case-control study of265patients with mite-sensitizedPER and275healthy controls, we genotyped seven single nucleotide polymorphisms(SNPs) in ADAM33. Serum levels of eosinophil cationic protein, total IgE andallergen-specific IgE against Dermatophagoides pteronyssinus andDermatophagoides farinae were measured by the ImmunoCAP.Results: In the single-locus analysis, a significantly increased risk of mite-sensitizedPER was associated with the GG genotype in ADAM33polymorphism S2(adjustedodds ratio [OR]=2.94,95%confidence interval [CI]=1.19-7.25), compared with theCC genotype. PER patients with asthma was significant associated with S2, T1, T2,T+1, and V4SNPs. In the combined genotypes analysis, individuals with3-6riskgenotypes had a significantly higher risk of mite-sensitized PER (adjusted OR=1.57,95%CI=1.05–2.36) than those with0-2risk genotypes. Haplotype-based associationanalysis revealed that the increased risk of mite-sensitized PER was significantlyassociated with haplotype CAGGCGC (adjusted OR=2.48;95%CI=1.14–5.41).Conclusion: ADAM33polymorphisms might contribute to susceptibility ofmite-sensitized PER in this Chinese population.