| Object:Doctors from generation to generation lay stress on dose-effect relationship of Chinese herbal medicine when they were handling clinical issues, which is directly related to therapeutic effect. There is an old saying,"the secret of Chinese medicine is the size of individual dose". So it is a pivotal point directly related to therapeutic effect. Doctors from generation to generation have summarized rich experience in their long-time clinical practice about the issue. Also dose-effect relationship of Chinese herbal medicine reflects clinical medication rule of Chinese medicine, which is the important base for BZLZ under guidance of the Chinese traditional theory. At the present time, with aged tendency of population, transformation to spectrum of disease and gradual increasing in drug resistance, complicated diseases appear. Development of collateral disease theory and the idea that "phlegm leads to the disease" make Chinese herbal medicine for activating blood and removing blood stasis and dispersing phlegm play a more and more important role when treating complicated diseases. In addition, climatic variation, change of environment for human survival and reduction of genuine medicinal materials cause that common usage can not satisfy clinical demand. Thus, it is very important and urgent that we make research on and analyze Chinese herbal medicine for activating blood and removing blood stasis and dispersing phlegm of classical prescriptions and then fix the best dose range, which is very significant.Method:The project is on basis of sorting out the theory of literature, systematically collects data and analyzes the dose range about the modern doctors, uses statistical method such as mean, percentile and range and then calculates a better dose interval, compared to Chinese Pharmacopoeia of2010. Meanwhile, we reflect the herbals’precise dose range of high frequency on the diagrams and charts, which can be used to instructing clinical medicine use and improving clinical efficacy.The research project uses Treatise on Exogenous Febrile Diseases and Synopsis of Prescriptions in the Golden Chamber as the base and choose more than twenty Chinese herbal medicines for or activating blood and removing blood stasis and dispersing phlegm. The list is as follows:Chuan Xiong, Tao Ren, Hong Hua, Shui Zhi, Mang Chong, Tu Bie, Ban Xia, Xing Ren, Gua Lou, J ie Geng, Bei Mu (including Chuan Bei and Zhe Bei), Xuan Fu Hua, Hai Zao, Zi Yuan, Kuan Dong Hua, Zao Jia, Ting Li Zi, Bai Qian and Zhu Ru. We take decoction as the example, retrieve the empirical prescriptions in the famous doctor’clinical records and then statistically process the collected original data so as to caculte the effective dose range for these herbals.Result:Through our detailedly retrieving about the twenty herbals in these famed doctors’records, we statistically process the collected original data by using mean, percentile and range, sum up the dose range of the twenty herbals when Chinese famed doctors were making a prescription and induce the most frequentest dose range. At last, we find that eighty percentage of dose range about the herbals we have researched does not match up to Chinese Pharmacopoeia of2010. So there is a difference between the dose range Chinese Pharmacopoeia sets and the actual dose range, which suggests that Chinese famed doctors didn’t comply wi th Chinese Pharmacopoeia when they were making the prescriptions.Conclusion:We contrast and analyze the original data systematically and find the dose range Chinese Pharmacopoeia sets is not absolutely accord with clinical practice. It restricts the clinical effect of the herbals. From our research, we come to the conclusion that the dose threshold and therapeutic window can be appropriately broadened on basis of Chinese Pharmacopoeia. |
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