Clincical Research Of Caihushugansan Joint Deanix For Postprandial Distress Syndrome (Liver-stomach Disharmony Syndrom)

Research purposes:To observe the clinical efficacy and safety of Caihushugansan joint Deanxit in the treatment of Functional dyspepsia Postprandial Distress Syndrome, and for clinical treatment Functional dyspepsia Postprandial Distress Syndrome provide the theory basis and explore the possible action mechanism.Method:The topic adopt the random digit form law select60cases who met the inclusion criteria for the clinical diagnosis of Functional Dyspepsia Postprandial Distress Syndrome, which were interviewed by Hamilton Depression Scale (HAMD)and Hamilton Anxiety Scale (HAMA), and the syndrome differentiation of disharmony between liver and stomatch. These patients were all selected Department of Gastroenterology outpatients in Hubei provincial Traditional Chinese Medical Hospital from March2010to November2011. According to the principle of matching test, the60cases were randomly divided into two groups,The treatment group has30cases and the control group has30cases too. The age, gender, disease, the severity of symptoms HAMD and HAMA were no signif iciant differences between the two groups (P>0.05), the study was comparable, treatment group Caihushugansan joint Deanxit treatment, control group mosapride joint Deanxit regimen. The periods of treatment in each group was4weeks.Informed patients not taking treatment of dyspepsia-related drugs thoughout the course of treatment, and told patients diet, to avoid raw foods,to avoid spicy foods,to avoid greasy and irritating foods,and so on. Both groups monitoring patients with vital signs before and after the experiment, and make general medical exam ination, such as blood, urine, stool tests and the function tests of heart, liver and kidney. After4weeks were compared the clinical symptoms、HAMD、HAMA、symptoms total score between the two groups before and after treatment and the clinical curative effect was analyzed.Result:In this experiment the treatment group showed a higher efficiency rate (93%) in compared to the controlled group (83%). The treatment group was better than the control group there was statistical significance (P<0.05). there were12cases with cure,10cases with marked effect,6cases with effect,2cases with no-effect in the treatment group; there were9cases with cure,5cases with marked effect,11cases with effect,5cases with no-effect in the controlled group. The two groups have significantly improved the symptoms in patients after the treatment, Comparing the controlled group, the treatment group showed a significant difference of statistical significance (p<0.05) of postprandial fullness,early satiety,belching the total score of HAMD and HAMA.Conclude:Caihushugansan joint Deanxit in the treatment of liver-stomach disharmony pattern of functional dyspepsia is safty and effective,and from the theory basis to explore its mechanism may be related to the following aspect:adjustment disorder neuroendocine function, achieve the neurotransmitter in the central nervous autonomic nervous adjustment, anti-anxiety and anti-depressant effect; increase gastric motility, and promote gastric emptying; ease gastrointestinal smooth muscle cramps, inhibiting gastric acid secretion, the method of soonthing the liver and harmonize the stomach has a better effect on treating Liver-stomach disharmony pattern of functional dyspepsia postprandial distress syndrome, which was worth being widely spreaded into application in clinic.