Expression And Significance Of CD10, CD34and α-SMA In Stromal Cells Of Benign And Malignant Breast Tumor

Objecive: To explore clinicopathologic expression of CD10, CD34andα-SMA instromal cells of benign and malignant breast tumor. Methods:200cases of breast tumordivided into4groups (usual ductal hyperplasia, atypical ductal hyperplasia, ductalcarcinoma in situ and invasive breast carcinoma), the expression of CD10, CD34andα-SMA were detected by immunohistochemistry in each group. Results:(1) Negativeexpressions of CD10in stromal cells in four groups.(2)The positive expressions of CD34in4groups are non-all the same（χ2=23.059，P=0.000）. The positive rate of invasivebreast carcinoma (32%) is lower than the other three goups.(3)The positive expressions ofα-SMAin4groups are non-all the sam（eχ2=33.713，P=0.000）. The positive rate of usualductal hyperplasia (62%) is lower than the other three groups. Conclusions: The changeof breast stromal, which rich in α-SMA(+) but lack of CD34(+), plays the important rolewhile breast benign tumor become malignant tumor.