The Clinical Observation And Animal Experiments On Yi Shen Qing Li Granule To Treat The Syndrome Of Dampness-heat And Kidney Deficiency Of Chronic Glomerulonephritis

Chronic glomerulonephritis, abbreviated to chronic nephritis, hematuria, edema, high blood Pressure as the main clinical manifestation,different onset of ways, protracted, slow progressed, and eventually will be developed to the chronic renal failure. In this disease, Dampness-heat and Kidney deficiency is important pathologic characteristic of chronic nephritis.Dampness-heat is both pathogenic factor and pathological product. Yi shen qing li Granule is consists of astragalus membranaceus, atractylodes macrocephala koidz, cornus officinalis, eucommia, oriental waterplantain rhizome, hedyotis diffusa and other traditional chinese medicine,which clears away heat,promotes dampness and tonifies Qi of the kidney.Thus Yi shen qing li Granules treat chronic glomerulonephrit of Dampness-heat with Kidney deficiency syndrome with the method of tonifiying Qi of the kidney,clearing away heat and promoting dampness.A、Yi shen qing li Granule for the rats particles Heymann glomerulonephritis roleTo Yi shen qing li Granule, shenyan kangfu pian treatment Heymann glomerulonephritis rats, Testing routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride) and the dynamic changes between before and after treatment. The results said:Yi shen qing li Granule obviously decreases the particles24-hour urine protein and serum creatinine, increases serum albumin, this drug reduceing serum creatinine,and increasing the role of serum albumin is better than the nephritis of rehabilitation.B、Yi shen qing li Granule for the rats C-BSA glomerulonephritis roleTo Yi shen qing li Granule, shenyan kangfu pian treatment C-BSA glomerulonephritis rats, Testing routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride)l and the dynamic changes between before and after treatment. The results said:Yi shen qing li Granule can reduce24-hour urinary protein and serum creatininc, to reduce the trend of albumin, rising trend for cholesterol have improved.C、To observe the clinical effects of Yi shen qing li Granule In treating Patienis with Dampness-hot and Kidney deficiency syndrome in chronic glomerulonephritis.This paper studies16patients of syndrome of Dampness-hot and kidney deficiency of chronic glomerulonephritis,they are treated by routine treatment+Yi shen qing li Granule. Observe the TCM symptoms, the clinical symptoms, test routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride)l and the dynamic changes of the before and after treatment. The results show that:before and after treatment, the TCM symptoms, the clinical symptoms improved significantly, routine urine (urine protein, urinary red blood cells),24hour quantitative indices such as urinary protein were significantly reduced.