Comparison The Effects Of Three Kinds Of Insulin Analogs Combination With Oral Antidiabetic Drugs In Type2Diabetes Mellitus Inadequately Controlled

Objective: To evaluate the efficacy and safety of insulin analogs(detemir, insulin glargine and Biphasic insulin aspart30) combination withoral antidiabetic drugs (OADs) in type2diabetic mellitus (T2DM) patientswhose blood glucose were insufficiently controlled.Methods: Seventy-three T2DM patients with insufficientlycontrolled blood glucose were assigned to three groups, one group withinsulin detemir once daily before bedtime (insulin detemir,n=23), onegroup treated with insulin glargine once daily before bedtime (insulinglargine, n=27), the other group treated with biphasic insulin aspart30twice daily before breakfast and dinner (BIAsp30，n=23), all with OADsfor16weeks. HbA1c, FBG, BMI were measured pre-treatment andafter-treatment. The reductions of HbA1c and FBG, the compliance rates ofHbA1c (<7%) and the incidences of hypoglycemia were compared.Results: There are no significant differences among the three groupsin HbA1c and FBG levels before the therapy.At the end of16weeks, HbA1c, FBG were decreased significantly in the three groups (P<0.01),and there was no difference of reduction of HbA1c, FBG in the threegroups (P>0.05). The BMI did not change significantly before andpost-treatment in the all groups. The compliance rates of HbA1c <7%were43%,59%,52%in insulin detemir group, insulin glargine group andBIAsp30group. The compliance rates of HbA1c <7%in the three groupsalso have no different (p>0.05).3patients (13%),2patients (7%),5patients (22%) had mild hypoglycemia in the three groups separately. Andthe frequency of hypoglycemia episodes was no significant in the threegroups (p>0.05). No severe hypoglycemia happened in the all groups.Conclusion: All the three kinds of insulin analogs could improveblood glucose control without weight gain, and have less hypoglycemiaepisodes. The effective control of FBG plays an important role in HbA1cattaining standard.