A Meta-analysis Of The Relationship Between NAT2Polymorphism And Colorectal Cancer Susceptibility

Objective: The aim of this study was to investigate the relationshipbetween N-acetyltransferase2(NAT2) polymorphism and colorectal cancer(CRC) susceptibility.Methods: Relevant literatures that had investigated NAT2polymorphism and CRC susceptibility were identified through acomprehensive search of Pubmed, EMBASE, Medline, Biosis,Wiley-Blackwell, ISI Web of Knowledge, CNKI and Chinese BiomedicineDatabase until October2011. Selection of literatures was done according tothe inclusion and exclusion criteria, and the relevant data were extractedfrom each study to perform a meta-analysis.Results: Eight phenotype studies (791cases and1158controls) and45genotype studies (13875cases and18879controls) were included inthe present meta-analysis. The pooling of phenotype studies showed nosignificant association between the NAT2acetylator status and CRC susceptibility (rapid acetylator OR=1.32,95%CI [0.92~1.89], P=0.14; slowacetylator OR=0.76,95%CI [0.53~1.09], P=0.14). The combined ORs forrapid and slow acetylator status and CRC risk in genotype studies were1.01(95%CI [0.94~1.08], P=0.86) and0.99(95%CI [0.93~1.06], P=0.86),respectively. In the subgroup analysis by regions, increased risks were notfound in Asians, Europeans, Americans or Australasians. Pooling studieswere also conducted on gender, specific tumor sites and smoking stategroups, results also showed no significant association in genotypedistribution between CRC and control.Conclusion: These results of our meta-analysis suggest that there isno overall association between the NAT2polymorphism and CRCsusceptibility.