The Correlate Research Between The Expression Of VEGF-C, VEGF-D And MMP-12and The Invasion And Metastasis Of Lymph Node In Non-small Cell Lung Cancer

OBJECTIVEThrough detection the expressions of VEGF-C, VEGF-D and MMP-12in thetissues of Non-small cell lung cancer and peritumoral, to investigate correlations withlymph node metastasis of NSCLC．METHODSExpressions of VEGF-C, VEGF-D and MMP-12in60cases of tissues ofNon-small cell lung cancer and peritumoral were detected by immunohistochemistry,their correlations with clinical-pathological findings and mediastinal lymph nodemetastasis of cancer tissues are analysed in patients．RESULTS1． The positive rates of VEGF-C，VEGF-D andMMP-12were96.7%％（58/60），93.3%（56/60），91.7%（55/60）respectively，which were significantlyhigher than those of the tissues of peritumoral（p＜0.01）．2． The expression of VEGF-C、 VEGF-D and MMP-12proteins inmediastinal lymph node metastasis of cancer tissues was significantly higher thanthe cases that without mediastinal lymph node metastasis of cancer tissues(χ~2=13.237，χ~2=6.960，χ~2=9.870；p=0.000, p=0.000, p=0.000).3． The expression of VEGF-C，VEGF-D and mmp-12proteins in NSCLCwere not correlated with gender，age，degree of differentiation and types ofhistological（χ~2=0.472；p=0.244），but correlated significantly with the stage ofPTNM（p=0．01）．Significant correlations between VEGF-C and VEGF-D（c＝0.331，p＝0.035），VEGF-C and MMP-12（c＝0.372，p＝0.016）,VEGF-D and MMP-12(c＝0.274，p＝0.041) expression were observed in mediastinal lymphnode metastasis of cancer tissues．CONCLUSIONS1. The expression of VEGF-C, VEGF-D and MMP-12proteins in the tissues ofNSCLC was significantly higher than the tissues of peritumoral.2. The expression of VEGF-C、VEGF-D and MMP-12proteins in the tissues ofmediastinal lymph node metastasis of cancer tissues was significantly higher than thecases that without mediastinal lymph node metastasis of cancer tissues.3. Significant correlations between VEGF-C and VEGF-D， VEGF-C andMMP-12,VEGF-D and MMP-12expression were observed in the MLNM ofNSCLC．4. The expression of VEGF-C，VEGF-D and MMP-12proteins in NSCLC werenot correlated with gender，age，degree of differentiation and types of histological，but correlated significantly with the stage of PTNM.