Clinical Research With Feiluo Ning Mixture On The Phlegm Heat Stasis Lung Of Acute Exacerbation Of COPD And Plasma Of NO, ET-1

Objective: To observe the Clinical Research with Feiluo ning Mixture on the phlegmheat stasis lung of acute exacerbation of COPD, as well as on plasma nitric oxide (NO),plasma endothelin-1(ET-1) level the impact of changes of the Feiluo ning Mixturetreatment of acute exacerbation of COPD of the mechanisms and significance, to providereliable experimental basis for clinical treatment of acute exacerbation of COPD.Methods: ninety patients with acute exacerbation of COPD of phlegm heat stasis ofthelung were randomly divided into three groups of30people each,30cases of thecombination therapy group (Chinese and Western medicine+Acupoint Application+antibiotics+bronchodilator+expectorant drugs),30cases of Chinese medicine treatmentgroup (medicine+Acupoint Application), Western medicine treatment group (antibiotic+Bronchodilators+expectorantdrugs)30cases.Treatment for14days. Observed before andafter treatment the patient’s symptoms, signs, blood gas analysis changes, using the ELISAmethod for the determination of plasma nitric oxide (NO), plasma endothelin-1(ET-1)expression levels to determine the clinical efficacy. SPSS17.0software is available for allexperimental data statistics.Results:The three groups after treatment, clinical efficiency and the signs andsymptoms There were significant differences (P <0.05), Chinese and Western medicinecombined treatment group, there are more efficient than the other two groups (P <0.05),and Chinese medicine treatment were excellent inWestern medicine treatment group (P<0.05); in improving blood gas analysis indicators, the three groups after treatment cancorrect the state of hypoxia and carbon dioxide retention (P <0.01), Chinese and Westernmedicine combined treatment group than the other two groups (P<0.05), Chinese medicinetreatment group was superior to Western medicine treatment group (P <0.05); plasma nitric oxide (NO) in the three groups after treatment, plasma endothelin-1(ET-1) levels thanbefore treatment were significantly different (P <0.05) elevated levels of plasma nitricoxide (NO)(P <0.05), plasma endothelin-1(ET-1) levels decreased (P <0.05), Chinese andWestern medicine combined treatment group than the other two groups (P <0.05), Chinesemedicine treatment group was superior to Western medicine treatment group (P <0.05).Conclusion: Feiluo ning Mixture treatment of COPD with acute exacerbation ofphlegm heat stasis lung patients with significant clinical effect. Effective improvement ofsymptoms and signs at the same time, significantly increased plasma content of NO,inhibition of plasma endothelin-1generation, which can reduce the airwayhyperresponsiveness and reduce airway inflammation, relaxation of vascular and bronchialsmooth muscle, purpose of reducing vascular resistance.