Chinese Medicine Treatment Of Perimenopausal Syndrome Clinical Study

Purpose:Observed of the climacteric syndrome in patients taking Gengnianle pill treatment efficacy. Combined with the KI scale, and sex hormone levels, blood pressure, blood rheology indicators to speculate that its mechanism of action.Method:Perimenopausal syndrome female patients to the Shiyan City Chinese Medicine Hospital of TCM gynecology clinic visits in line with the criteria for inclusion in March2010to2011November50cases, aged45-55years old45-50years old, which31patients with50-55-year-old19cases, with an average of48.83years of age; duration of4-36months,4-12months,15cases of24cases,24-36,12-24months by11casesan average of17.46months;18cases of postmenopausal patients,32cases of non-menopausal patients; severe illness were seven cases,30cases of patients with moderate, mild patients (n=13). Treatment of tutor Zhu name Chen prepared Gengnianle pill treatment prescription:Curculigo, Rehmannia, Angelica, salt Anemarrhena, Ligustrum lucidum, Morinda, salt Huangbai, Eclipta prostrata, Dodder, system Shouwu Epimedium, glutinous rice root, wolfberry fruit, raw keel, raw oysters, Lithospermum, yams, dogwood, Semen, Caulis, fried Atractylodes Zhigancao, taking a total of3months. Then compare the change in terms of clinical symptoms, sex hormone levels, bone metabolism values, blood flow changes in patients before and after treatment. Will observe the information and data sorting and statistical software to analyze (SPSS17.0):The measurement data using the t test; count data using x2test; and grade information Ridit analysis.Result:This group of50patients,5cases were cured,27cases, effective in14cases,4cases are invalid. The total efficiency of92%. The clinical symptoms improved markedly, especially Hongrehanchu, insomnia, anxiety, depression, suspicion and palpitations symptom improvement is obvious (P<0.01). KI scale and SCL-90scale score decreased, with significant difference (P<0.05). Serum estradiol was elevated, luteinizing hormone (LH), follicle stimulating hormone (FSH) were significantly decreased (P<0.05); urinary calcium/creatinine values decreased (P<0.05); adrenergic (ACTH), cortisol (CORT), blood rheology detection values such as erythrocyte aggregation index the indices of blood pressure pulse pressure drop, reduced (P<0.01or P<0.05).Conclusion:Gengnianle pill with Kidney replenishing essence, conditioning the role of yin and yang. The circumference can better improve the clinical symptoms of the menopause syndrome. Its mechanism may be regulated in patients with disorders of the hypothalamic pituitary-ovarian (HPO), the reproductive axis, increasing the level of estrogen secretion in vivo and improve autonomic dysfunction, regulation of bone metabolism, correcting body hypercoagulable state treatment purpose.