Effect Of Folic Acid On Nitric Oxide In Hypertension Patients With Hyperhomocysteine

[Objective] Folic acid is one of widely applied B vitamins in clinically, which is common in the application of cardiovascular diseases, and especially it can obviously reduce the plasma homocysteine (Hey) level. Our purpose is to explore weather folic acid reduces Hey and affects concentration of Nitric Oxide (NO) in plasma of the "H" type hypertension patients.[Methods] We collected50patients with "H" hypertension, and assigned to two groups randomly. One is control group, patients in this group only take anti-hypertension pills; and then another is folic acid group, which also taked high dose oral folic acid (10mg, tid) expect gived anti-hypertension pills. We take two picks from all patients and analysis the concentration of BH4and NO in plasma before and after two months.[Results] The concentration of Hey decreased in folic acid group, but increased in control group. What’s more, the effect is more obvious in the pure mutation of MTHFR gene than other genotypes. The concentration of BH4and NO increased in folic acid, while they decreased in control group. However, this change has not relation to MTHFR genotype.[Conclusion] Folic acid can protect endothelial function by increasing the concentration of BH4and NO, and there is no relationship between the effects of folic acid and MTHFR genotype.