The Role Of NF-κB Mediated Inflammatory Reaction And Type2Diabetes Mellitus In Coronary Atherosclerosis

Background: Chronic inflammation plays an important role in theformation and development of the atherosclerosis. In the beginning ofinflammatory response,the NF-κB, which is existed in endothelial cellsnecessary many cell factor, can specific bind the gene of promoter andenhancer element which transcription cytokines, adhesion factor; by thisway, the NF-κB participates in regulation of immune response,inflammatory reaction, cell differentiation and growth, cell adhesion andcell apoptosis. While Type2diabetes mellitus work as an independentrisk factor in the occurrence and development of atherosclerosis. How toeffectively control endothelial inflammatory reaction progress, controlmononuclear cell migration and differentiation, and ultimately controlprogression of atherosclerosis is still waiting for the new treatment ofcoronary heart disease (CHD).We compare the differences of NF-κBp65in the serum of patients who suffering angina to evaluate theimportance of inflammatory reaction in the occurrence of acute coronaryatherosclerotic and acute coronary atherosclerotic plaque rupture. Thisstudy also illustrates type2diabetes works as an independent factor toaccelerate inflammatory reaction in the occurrence of coronaryatherosclerotic. Finally,we demonstrate the NF-κB regulate ofinflammation reaction in coronary atherosclerosis.Objective: To illustrate the role of NF-κ B that participates in theregulation of inflammation in atherosclerosis and the rupture of unstableplaque, We observing the NF-κB content in serum of the Type2diabetes mellitus and non-Type2diabetes mellitus patients who suffering fromacute coronary syndrome and the difference of the NF-κB content inserum of the PCI treated group between the non-PCI treated group.Methods: We selected patients who had been done coronaryangiography from January2012to October2013in the CardiovascularDepartment, the second Bethune Hospital of Jilin University. We dividedthe patients into3different groups: Unstable angina (UA)group,Non-ST-segment Elevation Myocardial Infarction (NSTEMI) group andST-elevation myocardial infarction (STEMI).We observed the in serumNF-κB index with in24hours after coronary angiography.Results: The general clinical characters indicators of diabetic andnon-diabetic patients in the UA group, the NSTEMI group and theSTEMI group has no significant statistical difference (P>0.05). Thegeneral clinical characters indicators and risk factors between NSTEMIand STEMI group has also no significant statistical difference (P>0.05).The serum level of NF-κB p65of the patients with diabetes is higher thanthe non-diabetic patients in the UA group and the NSTEMI group withsignificant statistical significance (p=0.014in UA group, p <0.001inNSTEMI group); But there is no difference in the STEMI group. Theserum level of NF-κB p65of the patients in the STEMI group is higherthan NSTEMI group, with significant statistical difference（p=0.018）.The serum level of NF-κB p65of the patients between PCI treatment andnon PCI treatment in UA group has no significantly statistical differences.Conclusion:1, Inflammation is involved in the formation of coronary arteryatherosclerosis.2, The NF-κB inflammation is involved in coronary arteryatherosclerosis. 3, The NF-κB level in serum of coronary heart disease (CHD)combined with type2diabetes is significantly higher than non-diabetes’.