The Preparation And Properties Of Modilfed Bioactive Glass Composite Hydrogel Dressing

Recent studies show that bioactive glass has a good role in promoting the healing of skinwounds and is expected to become a new type of wound healing agent.The new type ofamorphous powders in system CaO-P2O5-SiO2with high bioactivity was synthesized viasol-gel method. In order to improve interface compatibility of the polymer and sol-gel derivedbioglass，3-aminopropyl-triethoxysilane(APS) was grafted on the surface of thebioglass.Whether APS was successfully grafted on SGBG and the graft rate in the reactionwere investigated by TG、DSC、SCA、BET、FTIR and XPS techniques. By using SEM、FTIR and XRD techniques and in vitro test， the rate of the calcium phosphatesmicro-crystals growth of BG and modified BG from the view of thecrystallography was investigated in detail after immersion in the simulated body fluid(SBF).The results showed that amino group functionalized mesoporous bioactive glasses hadbeen successfully fabricated through a post-grafting process. Silane coupling agent wascombined with bioactive glass by chemical bonds， and the bond energy was strong. Whenthe molar ratio of APS/SiO2was0.04:1， the graft ratio was maximized. The in vitrobioactivity results indicate that the morphology， the nucleation and growth rate of HA wereapparently affected by the introduced functional groups.The functional BG had a fastergeneration of HA and higher degree of crystallinity.The sol-gel bioactive glass can promote wound healing of diabetic and increase thehealing rate.Poly(vinyl alcohol)(PVA)/sodium alginate(SA) blend hydrogels have immensepotential for use as functional biomaterials.The purpose was to prepare BG、PVA and SAcomposite membranes with different ration by freeze–thaw method， and observe themorphological structure， the swelling degree， air permeability of the compositemembranes. The impact of the cross linker concentration and freeze-thaw cycles on waterabsorption， tensile strenth and air permeability of composite membranes was also discussedin the rearch.The study showed that the swelling ratio of the composite hydrogel was first increased and then reduced as the calcium chloride and sodium alginate concentration increasing andthe swelling ratio reached the maximum when the calcium chloride concentration was3mol/L and sodium alginate concentration was4%. With the number of freeze-thaw cycle andpolyvinyl alcohol concentration increasing， the swelling ratio presented a gradual trend ofgrowth. The tensile strength of the composite hydrogel was gradually increased with theconcentration of calcium chloride， the freeze-thaw cycles， polyvinyl alcohol and sodiumalginate concentration increasing. Meanwhile， the swelling ratio， tensile strength and airpermeability of the modified bioglass composite hydrogel have been greatly improved.