The Effect Comparision Of Living-Related Renal Transplantation With Donors From Different Age Group

ObjectiveThe objective of this study was to provide scientific basis for renal graft usage byinvestigating the effect comparison of living-related donor kidney transplantation (LDKT)with donors from different age-groups and analyzing different characteristics after trans-plantation.MethodWith the authorization from the relevant departments, we selected nine hundred andforty-three cases in four transplant centers from Chinese Scientific Registry of KidneyTransplantation (CSRKT). No prisoners or organs from prisoners were used in thecollection of these data. These graft recipients were divided into five groups: group1(range,≥60years), group2(range,50-59years), group3(range,40-49years), group4(range,30-39years) and group5(range,<30years).Then we made comparison of five groups of recipients in postoperative serumcreatinine and BUN level in different times (1week,1months,3months,1year,2years,3years after operation), operative complications and patient/graft survival rates by one year.By using the SPSS13.0statistical software, comparison between groups was used themethods of one-way analysis of variance (One-Way ANOVA) and multiple dependentsamples nonparametric tests (Kruskal Wallis H).1year recipient/graft survival rates usedthe methed of Life Tables survival analysisResultsNine hundred and forty-three cases of data from four transplant centers were dividedinto5groups accordance with age standards, in order to clear four transplant centers datadistribution, postperative immunosuppressive medication type proportion, ratio of men towomen, we used dependent samples nonparametric tests (The Kruskal-Wallis H Test), p >0.05.So cases were comparable. There were no significant between-group differences inthe incidence of postoperative acute rejection(AR) and delayed graft function(DGF).Thetreatment of6cases ineffective (above60years old in3cases,3cases under60years old);control or reversal63cases, the distribution in five groups is respectively8cases,23cases,15cases,8cases,15cases, that is respectively10.5%,7.5%,6.1%,5.8%and8.5%.Single factor analysis of variance (One-Way ANOVA) showed no statistically significantdifferences: p=0.629.Delayed graft function: a total of36cases, the occurrence rate of3.8%. The shortest recovery time was5days, the longest163days. The five groups arerespectively1,10,7,7,11cases, which is respectively1.3%,3.3%,2.8%,5%and6.3%.Single factor analysis of variance (One-Way ANOVA) showed no statistically significantdifferences: p=0.233.Pulmonary infection: a total of60cases, the occurrence rate of6.4%,treatment failure4cases. The distribution in five groups is respectively5cases,15cases,12cases,12cases,16cases, occurrence rate is respectively6.6%,4.9%,4.9%,8.6%and9.1%. Single factor analysis of variance (One-Way ANOVA) showed no statisticallysignificant differences: p=0.247. Other:3cases of urinary tract infection, unspecifiedinfection in4cases,1case of renal vein thrombosis,1case of hemorrhage of digestivetract,1case of renovascular hypertension,1case of chronic hepatitis B. There were nosignificant differences between the study and control groups in1year recipient/graftsurvival rates (p>0.05).ConclusionsThere was no significant difference between different age groups in renal functionrecovery after transplantation. Postoperative complication rates were with no fardistinctions. Early results are satisfactory. So the age of living-related donor kidney shouldnot be absolutely confined but be relaxed appropriately under the condition of the seriousshortage of donor age. The long term effect of transplantation, still need further research.