Correlation Between HbA1c And CK, CK-MB And CK-MB/CK Ratio In The Elderly Diabetes Mellitus Patients With Acute Myocardial Infarction

ObjectiveTo investigate the correlation between HbAlc and CK, CK-MB and CK-MB/CK ratio in the elderly type2diabetes(T2DM) patients with acute myocardial infarction(AMI).MethodsThe120patients were divided into five groups according to the level of HbAlc: A group(HbAlc:4.00%-5.99%); B group(HbAlc:6.00%-6.99%); C group(HbAlc:7.00%-7.99%); D group(HbAlc:8.00%-8.99%); E group(HbAlc:≥9.00%), The CK, CK-MB and CK-MB/CK ratio were measured in all the cases. At the same time, we collected the biochemical characteristics and common data of these patients.Results1. There was no significant difference on sex, age, smoking history and hypertension among the five groups (P>0.05). SBP and DBP of Group B were both higher than Group D (P<0.05)2. CK and CK-MB of Group A were both the lowest among the five groups, and there had significant difference than Group E (P<0.05)CK-MB/CK ratio of Group C was the lowest, and there was significant difference than the other four groups (P<0.05)LDH was significantly higher than Group B and Group C (P<0.05) TC was significantly lower than Group C and Group E (P<0.05)At the same time, there was no significant difference on cTnT, TG, HDL-C, LDL-C of the five groups (P>0.05)3.HbAlc was positively related with FPG and LDL-C (P<0.05)Conclusions1. There was no significant correlation between HbAlc and sex, age, course of disease, smoking history, hypertension. These factors would independently effect on the development and progression of elderly diabetes and myocardial infarction.2. CK-MB/CK ratio could better show the myocardial injury than CK, CK-MB, LDH, cTnT in the early. While HbAlc controlled in7.00%-7.99%, CK-MB/CK ratio is the lowest, so that myocardial damage of the elderiy T2DM patients with AMI is the smallest. TC would rise as glucose, it prompted that the blood sugar always elevated along with high cholesterol.3. HbAlc was positively related with FPG and LDL-C. It showed us when the two factors were abnormal, we should pay more attention to cardiovascular infarction in elderly diabetes patients, to avoid the misdiagnosis and missed diagnosis.