The Magnetic Resonance Spectroscopy Study Of Intervention On Vascular Cognitive Impairment No Dementia Treated By Modified Shuyu Pill

ObjectiveVascular cognitive impairment without dementia is the earlystages of vascular cognitive dysfunction impairment,do notdeveloped to the level of vascular dementia, Early diagnosis andtreatment can delay its progress to vascular dementia, has anextremely important significance for the treatment of vascularcognitive impairment.To observe the intervention effects ofModified Shuyu Pill(MSP) on vascular cognitive impairment nodementia(VCIND) and the change of magnetic resonance spectroscopyin patients with VCIND.MethodsTo screen the outpatient and inpatient department patients inHubei Province Traditional Chinese Medicine Hospital, WuhanUniversity People’s Hospital from December2009to December2011,find the100patients agreeed to the requirement which meetdiagnostic criteria and inclusion criteria of VCIND. Then,100patients with VCIND were randomly divided into experimental groupand control group. On the basis of the treatment against riskfactors，the experimental group was treated by MSP and the controlgroup was treated by donepezil hydrochloride respectively.Theneuropsychological scales MMSE and MOCA score、 the metabolic values of MRS and the adverse reactions were observed.Results①The neuropsychological scales MMSE and MOCA score of bothtreatment groups were increased compared with the score beforetreatment (P＜0.01).②There were no significant differences in MMSE and MOCA scorebetween the two groups（P＞0.05）③After taking MSP,the level of Cho/Cr in right angular gyrusand left thalamus was significantly lower（p＜0．05；p＜0．01）,thelevel of NAA/Cr in right thalamus and right hippocampus wassignificantly lower（p＜0．01；p＜0．05）；④After taking donepezil hydrochloride, the level of Cho/Cr inleft thalamus was significantly lowe（rp＜0．05）, the level of NAA/Crin right hippocampus was significantly lower（p＜0．05）⑤The effects of blood, urine, stool, liver and kidneyfunction、 ECG showed no abnormality in the two group. Thetreatment group does not appear significant adverse reactions,thecontrol group have8cases with insomnia(3case off)、2cases withdiarrhea (off)、2cases with headache.ConclusionThe traditional Chinese medicine MSP can effectively intervenein the progression of VCIND and the mechanism maybe throughregulating the cholinergic nervous system and repairing the cranialnerve.