| backgroundBecause of unhealthy eating habits and way of life, the influence of type2diabetes mellitus (type2diabetes mellitus, T2DM) incidence increase year by year. AS is known to all, T2DM complications caused by more serious than T2DM is much more complex, most of T2DM complications on the microscopic study can be classified AS a blood vessel complications, mainly involving the target organs of blood supply arteries, such AS diabetic eye disease, foot disease, kidney disease, heart disease, brain, etc., their common pathological basis for atherosclerosis (atherosclerosis, AS), resulting in a series of ischemia anoxic damage of target organs. T2DM patients with vascular complications of acute myocardial infarction, stroke and other cardiovascular emergency events is much higher than the incidence of diabetes, mostly AS vascular lesions cause diabetes one of the main causes of high mortality and high morbidity. Inflammation of the current generally accepted theory is a common pathophysiological basis of T2DM and AS one of change. And widely known to the inflammatory response in the whole development process of atherosclerosis plaque play an important role, is closely related to the AS. Hot spot in recent years, studies have shown that CRP (C-reactive protein, CRP) not just inflammation markers, also involved in the occurrence and development process of the AS. Hypersensitive c-reactive protein (high sensitive C-reactive protein, hsCRP) is based on the content of serum CRP biochemical measurement inspection technology, higher sensitivity than conventional CRP can correctly reflect the actual level of inflammatory factors and dynamic change, so as to more accurately judge the severity of the inflammatory response. AS mainly large, medium artery vascular lesions, the carotid atherosclerosis, carotid atherosclerosis, CAS) lesions with most arteries atherosclerotic lesions have the same pathological base, so AS to know AS lesion degree of a window, plus carotid artery location shallow, easy detection by color doppler ultrasound technology, and the economic, accuracy and repeatability are high, so the carotid artery ultrasound for CAS lesion degree of a convenient tool.purposeThis study was to explore color doppler ultrasound in type2diabetes mellitus accompanied by abnormal hypersensitive c-reactive protein in patients with carotid atherosclerotic lesions degree of clinical significance and value.methodsSelect disabled soldier general hospital in shandong province in February2012to February2013admitted68patients with type2diabetes, the male52cases, female16cases. Age between52-75years old, average66.2+/-5.9years old. Selected patients clinical diagnosis are meet ADA (American diabetes association),2010diabetes diagnostic criteria, and eliminate infection, tumor, diseases of the immune system and liver and kidney function not congruent. To detect as T2DM group, the patients serum hypersensitive c-reactive protein, which was divided into the experimental group, the negative is divided into the control group. Another select the hospital outpatient service and the physical examination center over the same as normal group of30cases of healthy physical examination, including (20male and female10cases, age43-69-s, an average of56.2+/-4.7years old. Rule out the above standard. The detection of hsCRP. Using high frequency color doppler ultrasonic diagnostic instrument testing of above three groups of patients with carotid artery intima-media thickness (intima-media thickness, IMT) and plaque formation. Patches are divided into two kinds:the properties of stable plaques and vulnerable plaques. Calculated from three groups of plaque detection rate, further analysis of the nature of the plaques and record.result1. The experimental group for the detection of hsCRP positive32cases of patients with type2diabetes,18patients with varying degrees of plaque formation; The control for the detection of hsCRP negative36patients with type2diabetes,4cases with different degree of plaque formation; Normal group of30cases of hsCRP were negative, no case of plaque formation, resulting in plaque detection rate and the nature is not two two compared with other two groups.2. The T2DM group (experimental group+control group) compared with normal group, hsCRP positive number difference was statistically significant (p<0.05).3. Compare three groups IMT, the experimental group (1.22+/-0.12mm)> control (1.03+/-0.11mm)> the normal group (0.89+/-0.10mm). Compared three groups of two:the experimental group and control group difference was statistically significant (p<0.05); The experimental group and normal group difference was statistically significant (p<0.05); Normal group there was no statistically significant difference with control group (p>0.05).4. The experimental group compared with control group plaque detection rate, the experimental group (56%)> the control group (11%), are similar between the two groups have statistical significance (p<0.05).5. The comparison of experimental group and control group patches properties, experimental group18cases plaque vulnerable plaques in13cases,4cases were plaque unstable plaques in0cases, compared two groups was statistically significant difference (p <0.05).conclusion1. T2DM hsCRP were higher than that of normal people in the crowd.2. Merger of T2DM hsCRP was the IMT was higher than negative dre and normal people without T2DM. HsCRP high-risk T2DM patients with IMT and there is no significant difference between normal healthy people. Prompt hsCRP play an important role in the CAS.3. HsCRP affect the incidence of T2DM patients with carotid plaques and stability.4. T2DM with hsCRP was abnormal can be by color doppler ultrasonic testing the nature of the carotid artery intima-media thickness and plaques, screening to confirm the CAS, effective prevention of T2DM caused by cardiovascular emergency events. High accuracy, good repeatability, has higher clinical value. And ultrasound itself economy is convenient, safe and non-invasive, easy to accept. |
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