| Objective: Functional dyspepsia is a digestive department commondisease, frequently-occurring disease, clinical mainly characterized bypersistent or recurrent epigastric discomfort, abdominal bloating, postprandialfull bilge, belching, early satiety, anorexia, nausea, vomiting, heartburn andother symptoms of digestive disorders. European and American countries FDincidence is19%~41%, the domestic is18%~45%, accounted for20%~40%of digestion of outpatient service. The disease patients often accompanied byvarying degrees of anxiety depression, seriously affect their quality of life,study, work and life greatly. Although at present western medicine has definitetreatment, but no significant clinical effect. FD belongs to Chinese medicinedistention and fullness, vomit, category, through clinical observation, we thinkthe disease pathogenesis of diseases with stasis, spleen and stomach weakness,the lesions in the stomach, liver and spleen, the change. Tutor combinedwith clinical experience, select the radix bupleuri, atractylodes, etc, altogether13ingredients of traditional Chinese medicine, Shu Gan Jian Pi decoctionwith Deanxit force to change type FD with depression effect of clinicalresearch, to the clinical treatment of functional dyspepsia associated withdepressive state to provide certain ways and methods.Methods:1Clinical dataAccording to Roman Ⅲ diagnostic criteria in2002[1], the ministry ofhealth of the People’s Republic of China "Chinese traditional medicine newdrug clinical research guiding principle"(trial)[2]in the "Chinese medicineclinical research guiding principle of the new drugs with" relevant content,and in2001the Chinese institute of traditional Chinese medicine medicalprofessional committee of the spleen and stomach disease, the13th conference by the functional dyspepsia TCM diagnosis and treatment standard (draft)[3]about content, self-test and the depression scale (SDS) score, will conform tochange the type of FD with depression diagnostic criteria of the outpatientservice patient100examples, according to the clinic on the order, inaccordance with the principle of random grouping, each50cases were dividedinto treatment group and control group, treatment group drug for Shu Gan JianPi decoction and party with Deanxit; The control group for domperidone andDeanxit.2Drug useDeanxit in the treatment group and the control group,1times1capsule,1-2times a day, morning, noon warm water take. Oral treatment group of Shugan jian pi decoction addition and subtraction,150ml,2times a day, sooner orlater,2hours after breakfast and dinner by mouth. Control team motilium,1times20mg,3times a day,3meals of warm water20minutes before serve.3The observation of curative effect and securityLooks for1month after two groups of patients with the TCM symptomscurative effect of integral and SDS score changes, were observed before andafter treatment of laboratory safety indicators such as blood routine, urineroutine, and routine, liver function (ALT, AST), kidney (BUN, Scr), etc.4The statistical methodsAll the data use SPSS13.0statistical software for statistical analysis.Measurement data before and after their compared with Paired t Test (PairedSample, t Test), using two Sample t Test is compared between groups(Independent-Sample t Test). Count data using Ridit analysis, P<0.05as thereare significant differences.Results:1Disease curative effect analysis: the treatment group (50cases,24casesgot cure,15cases were markedly effective,9cases of effective and ineffectivein2cases, total effective rate96.0%; Control group50cases,15cases gotcure,14cases had marked effect,12cases,9no effect, the total effective rate82%, compared two groups of clinical curative effect, total effective treatment group was obviously higher than that of control group, there was significantdifference (P<0.05).2Improve TCM symptoms integral analysis: symptoms before treatmentto the total integral: treatment group was18.37±1.66, the control group was19.26±1.98, two groups of cases of symptoms before treatment to the totalscore was no significant difference (P>0.05), comparable; After treatmentsymptoms total score:5.37±1.32in treatment group; Control group10.36±4.65, two groups of symptoms after treatment the total integral comparisonhave significant difference (P<0.01); Treatment group and control groupbefore and after treatment with hou total integral comparison in the group alsohad significant difference (P<0.01).3The SDS score improvement analysis: two groups of cases total SDSscore before treatment: treatment group was59.65±3.16, the control groupwas57.46±5.54, two groups of cases total SDS score before treatment was nosignificant difference (P>0.05), comparable; Two groups of cases total SDSscore after treatment: the treatment group was36.87±1.27, two groups ofcases, control group was45.72±3.59, total SDS score after treatmentcompared with significant difference (P<0.01); SDS before and after treatmentin treatment group and control group total score comparison in the group alsohad significant difference (P<0.01).Conclusion:1Compared with the control group, Shu Gan Jian Pi decoction canreduce the improvement symptoms of the type of functional dyspepsiatreatment was statistically significant (P<0.05), Shu Gan Jian Pi decoction canobviously improve indigestion symptoms of FD.2Compared with the control group, Shu Gan Jian Pi decoction can treatdepression status was statistically significant (P<0.01), Shu Gan Jian Pidecoction can improve the depressive state of patients. |
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