Tcm Syndrome Characteristics Of Coronary Heart Disease (chd) With Type 2 Diabetes And Coronary Artery Lesions In The Correlation Research

BackgroundCardiovascular Disease(CVD) topped the list of constitution of the cause of death. Diabetes Mellitus(DM) influences CVD as well. The product effect of Coronary Heart Disease (CHD)with DM accelerated the progression of atheroselerosis. Therefore, DM was ranked as the equivalent risk of CHD. When cardiovascular risk factors are same,the prognosis and mortality of CHD with DM is twice as CHD with non-DM in the experiments about CVD. What’s more,some study had been certificated that some treatments may accelerated the progression of disease. For example, thiazolidinediones (TZDs) result in water retention and blood volume increasing,and relating to the increasing risk of HF.The sulfonylureas could accelert the risk of the coronary spasm.The morbidity of DM was growing up30-40million every year. Becides,more and more young fellow were suffering from it. With the increasing mortality, CHD with DM had been taken seriously, which threaten the living of morden human, including quality and safety of life.Traditional Chinese Medicine(TCM) had seperately discoused symptoms and treatments in the following eategories,such as XiaoKe,Obstacle of Qi in the chest、Heart-Throb, and so on. After that,compared with morden medical skills and verteran clinical experience summary, the further pathogenesis had been realized. The main reason is about natural endowment deffeciency、post-natal insuffeciency including improper diet、lack of exercise、 the obstacle of Qi、excessive comfortale,etc.Phlegm and blood stasis which were the main pathogenie products,accelerated the progression of the disease. In clinical treatment, the vatal method was combination of disease differentiation and syndrome differentiation. The familiar syndromes were Qi-yin dificiency、phlegm and blood stasis、Qi stagnation and blood stasis、Yang dificiency and blood stasis. Because of pertinencion experienments and insuffecion sample size, the disease syndrome classification hadn’t got an unified standard, therefore, the reserch of differentiation of symptoms for classification in CHD with Type2DM had significance.ObjectiveTo study the feature of pathological process situation of coronary artery,feature of syndrome of chinese medicine between CHD complicating DM and CHD.To analyze the relationship between the result of opacification of coronary artery and the complications of DM. MethodTo collect116medical history of the in patients who were in internal medical in Cardio intervention center in the Xiyuan hospital,China Academy of Chinese Medicine Science and whose results of opacification of coronary artery is detail, then divide the data into two groups, Group DM50and Group Non-DM66. To compare the clinic basical data, pathological changes feature of coronary artery, feature of chinese medical syndrome between the two groups statistically.Results1.Age:The rate in the male which complicating with CHD aged from50to80was significantly higher than the female of the same age stage in Group DM.2.risk factors:There is obvious difference between Group DM and Group Non-DM that complicating with risk factors about HBP、Hyperlipemia, and there is no obvious defference between Group DM and Group Non-DM that complicating with smoking、drinking(p>0.05).3. The pathological changes are satistically significant among2Groups(p<0.05); Spearman rank correlation test showed that between HbA1c level、FBG level、2hPG level and number of diseased coronary branches has a positive correlation(r=0.747,0.681,0.539, P<0.01); between HbAlc level、 FBG level、2hPG level and Gensini’s score has a positive correlation(r=0.872,0.814,0.752, P<0.01),between HbA1c level、FBG level and Gensini’s score has a line relashionship.4. The main chinese medical syndrome of Group DM is Diffeciency of yin and phlegm turbid., blood stasis through the process of CHD.There is no significant deviation in the dependablity of chinese medical symptoms, tongue coating, pulse pattern between the two groups.ConclusionThe hackneyed and important clinical syndromes of CHD with Type2DM were Yin insufficiency and phlegm stagnation,blood stasis through the process of CHD.The other hand, compared with CHD with non-DM, the pathological changes of the coronary in CHD with Type2DM are more severe. HbA1c、FBG play a certain role to determine the exent and severity of coronary arterylesion.