Urinary Bladder Cancer Antigen And Nuclear Matrix Protein 22 The Clinical Value Of Diagnosis Of Bladder Cancer

Bladder tumor is the most common tumor of the urinary system, in which the most commonone is bladder transitional cell carcinoma. The biological behavior of BTCC are complex andchangeable and performs easy recurrence, multiple, and invasion and metastasis, thus affectingthe diagnosis and treatment of bladder cancer. Diagnosis of bladder cancer depends mainly oncystoscopy, but because of its invasive and the needs of the operating environment does notapply to bladder cancer screening, other screening methods such as urine cytology has highspecificity but poor sensitivity, the general ideal for early diagnosis and monitoring of bladdercancer should be non-invasive, and also has good sensitivity and specificity, and easy to operate,low-cost. Therefore, clinical research focus on looking for high sensitivity, specificity,noninvasive method to facilitate group screening of bladder cancer. Establish a rapid, specific,non-invasive detection method is conducive to bladder cancer, early diagnosis, in particular, areimportant for monitoring recurrence after treatment.Objective: To assess the diagnostic value of testing of urinary bladder cancer antigen (UBC)and nuclear matrix protein 22 (NMP22) in the detection of bladder cancer.Methods: This study included 70 bladder cancer patients and 23 urinary benign diseasepatients. The examinations of UBC and NMP22 by ELISA. After that, urine cytology wereperformed.Results: Results:1. The sensitivity of UBC 84.3%(59/70) and NMP22 81.4%(57/70) was significantlyhigher than that of urine cytology 95.7%(22/23).2. The specificity of UBC and NMP22 and urine cytology was 82.6%(19/23), 65.2%(15/23)and 95.7%(22/23), respectively; there was no significant difference among these 3 methods.3. The sensitivity of UBC and NMP22 was also significantly higher than that of urinecytology in different histologic stages and grades. The sensitivity of UBC and NMP22 was notsignificantly different among different histologic stages and grades. However, the sensitivity ofcytology was improved with the higher grade of bladder cancer but there was no differenceamong histologic stages. Conclusions: The study indicates that UBC and NMP22 are bettermethods with non-invasion and higher sensitivity in diagnosing bladder cancer.Conclusion: The study indicates that UBC and NMP22 are better methods withnon-invasion and higher sensitivity in diagnosing bladder cancer.