Study The Mechanism Of Bladder Cancer Induced By Terephthalic Acid

Terephthalic acid (TPA), one of the most commonly produced chemicals in the world, had been extensively used for the synthesis of certain crystalline polyester resins, films, and fibers, etc. TPA has been considered to be a non-genotoxic chemical compound and it is low toxicity. However, there are disputes about how TPA induces bladder cancer. To elucidate the mechanism of bladder cancer induced by TPA, especially the molecular mechanism, and to provide more information for rationally evaluating the potential risks of TPA, we investigated the relationships among bladder stone, urinary precipitate, bladder cancer, and the chemical itself based on the two-stage and middle-term bladder carcinogenesis model.Part I The Role of Terephthalic Acid in the Rat Bladder CarcinogenesisObjective: To examine the effect of TPA on urinary bladder carcinogenesis. Methods: Male Wistar rats were initiated by injection of...