Peptic Ulcer Disease Syndromes And Syndrome Factor Distribution Characteristics Research

Objective:As a common disease of the digestive system,Peptic ulcer is global distribution.With the promotion of drugs of inhibiting gastric acid and anting Helicobacter pylori infection,significantly the morbidity and mortality are reduced.However,the high rate of recurrence of this desease,continual rising rate of H.pylori resistance and the boring side effection of the drugs gradually attract people’s attention.The study found that Chinese medicine to improve ulcer healing quality,reduce the relapse rate,anti-HP infection and relatively few adverse reactions has more prominent advantages.actively and effectively to promote Chinese medicine in the development of these areas will be profound.To play the advantages of Chinese medicine lies in the efficacy,which is good or bad depending on a scientific TCM syndrome diagnostic criteria.In view of our current peptic ulcer syndrome diagnosis standards are not unified, less standardized, restricted the development and promotion of Chinese medicine for the treatment of the disease.Therefore,making a standardized and unified PU syndrome diagnosis standands is the focus of this work.The purpose of this study is to investigate the PU’s syndrome and syndrome element distribution characteristics, in order to lay the foundation for the establishment of peptic ulcer syndrome diagnosis standards.Methods:This study is composed by two parts of the literature research and clinical studies:(1)Literature research part:Adopting literature analysis method to retrieve literatures referring to TCM syndrome type of PU from the data base-HowNet and VIP information,classfy and unify syndromes of similar meanings,and describe PU’s syndrome and syndrome element characteristics with the frequency analysis.(2)Clinical research partrAdopting cross-sectional survey methods of clinical cases,collect196cases of PU patients from outpatient and inpatient then collecting demographic data,disease-related information, clinical manifestations and diagnostic results of the cases.Using the messages above to make a database,adopt frequency statistics to describe the characteristics of gender,blood type,age and clinical manifestations;Use the chi-square test to study relationship between PU typles,PU stages and syndromes;Lastly,use factor analysis and cluster analysis to extract syndromes and syndrome factors.Results:(1)PU syndrome typles based literature analyse include deficient of spleen and stomach, disharmony of liver and stomach,Stagnation stomach meridian,yin deficiency of stomach,stomach heat flaming,damp-heat blockage etc.Disease-bit elements includes stomach,liver,spleen.Excess pathogenic factors includes heat,dampness,qi stagnation,blood stasis;Deficiency pathogenic factors are yin deficiency,qi deficiency,yang deficiency.(2)Clinical patients’syndrome typles include deficient of spleen and stomach,disharmony of liver and stomach,Stagnation stomach meridian,yin deficiency of stomach,stagnated heat of liver and stomach,damp-heat blockage etc.As one part of syndrome elements,pathogenic factors include excess and deficiency. Excess syndrome includes heat,dampness,qi stagnation,blood stasis;Deficiency syndrome are yin deficiency,qi deficiency,yang deficiency.Disease-bit elements includes stomach,liver,spleen.Compared with factor analysis,the qi deficiency and blood stasis patten is different from the Stagnation stomach meridian.Meanwhile,the syndrome elements are the same as factor analysis.Conclusions:The results of factor analysis and cluster analysis and the results of literature statistics are similar,which suggest multivariate statistical analysis may do a favor for related research of multifactorial TCM syndrome.