The Intervenient Effect Of A Modicum Of Sodium Salicylate On The Aerobic Metabolism Key Enzyme Of Mice’s Skeletal Muscles

Research Purpose:The research analyses the transformational laws of the content of pyruvic acid,succinodehydrogenase and malic dehydrogenase of the mice in a peaceful and exhaustiblestate, after it was injected with10mg/kg to50mg/kg’s little sodium salicylate. This articleillustrates the effect of little sodium salicylate on mice’s skeletal muscle’s aerobic metabolism,in order to provides experimental support to the research of little sodium salicylate inanti-fatigue field.Research Methods:The research objects are ninety-six male mice, which were divided into twelve groups inrandom, eight mice for each group. These groups have their own assignment and name, suchas contrasting quiet group, contrasting exhaustion group; experimental quiet Ⅰ group,experimental exhaustionⅠgroup; experimental quiet Ⅱ group, experimental exhaustion Ⅱgroup and so on.First, we will get the quadriceps femoris of the mice in quiet group one hour later after itwas injected with drugs. Then mice in exhaustion group will swim after it was injected for anhour. At last, we will take the quadriceps femoris from the mice and check the liveness ofsuccinodehydrogenase, malic dehydrogenase of the skeletal muscles of the mice.Research Results:(1) The content of pyruvic acid: the pyruvic acid content of contrasting exhaustion groupis higher than quiet group (p<0.05); the experimental quiet group is higher than contrastingquiet group (p<0.01); the content in experimental exhaustionⅠgroup to Ⅳ group is higherthan in contrasting exhaustion group, and the content will gradually change with the increaseof the dose of sodium salicylate. Moreover, the content in experimental exhaustionⅠgroup hasdifferences (p<0.05).(2) The content of succinodehydrogenase: the content ofsuccinodehydrogenase in contrasting exhaustion group is lower than in contrasting quiet group(p<0.01); and the content in experimental quietⅠgroup to Ⅳ group is higher than incontrasting quiet group (p<0.01); the content in experimental exhaustion group is higher thanin contrasting exhaustion group (p<0.01).(3) The content of malic dehydrogenase: the contentin contrasting exhaustion group is lower than in contrasting quiet group (p<0.01); the content in experimental quietⅠgroup to Ⅳ group is higher than in contrasting quiet group (p<0.01);the content in experimental exhaustionⅠgroup to Ⅳgroup is higher than in contrastingexhaustion group (p<0.01).Conclusions:To a certain extent, little sodium salicylate can improve the content of pyruvic acid ofmice’s skeletal muscle, and the liveness of malic dehydrogenase and succinodehydrogenase.What is more, little sodium salicylate can enchance the ability of mice’s aerobic metabolism.The effective dose is between10mg/kg to40mg/kg, and its effect will strengthen with theincrease of concentration. The best dose is40mg/kg. Besides, the40mg/kg sodium salicylatecan provide abundance of energy to the mice by enhancing organism’s aerobic metabolismability.