Synthesis, Antibacterial Activity Of Transition-Metal Complexes With2-Pyridinecarboxaldehyde And Aromatic Amine Schiff Base

2-Pyridinecarboxaldehyde is a kind of pharmaceutical chemicals and fine chemical engineering materials.2-pyridinecarboxaldehyde condenses with amino to form Schiff bases conjugate system containing N, N atoms of pyridine ring and C=N which can form functional complexes with metal ions. Copper and zinc are essential life elements, they have an important physiological role in maintaining normal metabolism of organisms. Schiff base and its transition-metal complexes have received considerable attention due to the wide variety of biological activities such as antibacterial, antiviral, anticancer, antineoplastic, antituberculous activities,In this paper, six different types of Schiff base ligands were synthesized using2-pyridinecarboxaldehyde and six kinds of aromatic amines; eleven different types of complexes were synthesized using these ligands. These ligands and their complexes had antibacterial activities against escherichia coli, staphylococcus aureus, bacillus subtilis. The antibacterial activities were tested by measuring the diameters of the bacteriostasis circles. Its main contents and conclusions of the study were as follows:1. Six different types of Schiff base ligands were synthesized using2-pyridinecarboxaldehyde with six kinds of aromatic amines of aniline,2-methoxy aniline,3-methoxy aniline,4-methoxy aniline,4-nitro aniline,4-methyl aniline. Six ligands were characterized by1H NMR,13C NMR and IR spectra.Eleven different types of complexes were synthesized using these ligands with copper chloride and zinc chloride.Their structures were characterized by elemental analysis, molar conductance, IR spectra, UV-vis spectra, TG/DTG. 2. The antibacterial activities of Six Schiff base ligands ligands and eleven complexes against escherichia coli, staphylococcus aureus, bacillus subtilis were tested by measuring the diameters of the bacteriostasis circles. All the research results showed that Schiff base ligands and complexes all had antibacterial activities; the antibacterial activities of complexes were stronger than ligands; when the ligand was same, the antibacterial activities of zinc(II) complexe were stronger than copper(II) complexe; and the antibacterial activities had something to do with different bacterium types.