Quantitative Predictive Value Of Carotid Artery Ultrasonography To Coronary Artery Stenosis

Objective Through contrasting IMT that were examined by carotid arteryultrasonography and the result of CAG from patients who probably suffered CAD byclinical symptoms, we analyzed the relative degree. By ROC curve, we computed thebest point to evaluate the coronary artery stenosis.Methods Choosing76patients(Male:53; Female:23. Age:34-81years.) fromYan’an University affiliated hospital Dong Guan hospital, from March2012-July2012.Appling ultrasonography to examine IMT and coronary angiography to examinecoronary artery, finally, we contrasted the IMT and the results of CAG. we analyzed thepredictive value of IMT to CAD through ROC curve and found the best critical point,calculating the sensitivity (Sen), specificity (Spe), positive predictive value (PPV) andnegative predictive value (NPV) of the IMT evaluation of coronary heart disease.Results (1) IMT increased as aging;(2) AS is a chronic process, whatever theabnormal degree, e.g. increasing IMT, forming plaque, even producing artery stenosis,once detecting abnormal artery, the person should receive some intervention method, e.g.adjusting life style, treating by drugs, or PCI. So from this aspect, examining for mildAS(even the preclinical AS), has important value. It can distinguish the normal tissue andthe abnormal tissue.①If defining carotid BIF-IMT≥1.0mm as abnormality, then thePPV, NPV for any degree of coronary stenosis are96.0%(48/50),23.1%(6/26). As theNPV is low, we consider that if the patients who suffered chest pains have normal carotidultrasonography results, then we remain can’t predict that coronary artery is normal.②If we defined the coronary stenosis≥50%for CAD, then the PPV, NPV were88.0%(44/50),46.2%(12/26).③The cardiovascular events were usually caused by the stenosis≥75%. So detecting the stenosis≥75%has important clinical value. Andthe PPV, NPV were80.0%(40/50),50.0%(13/26).(3) In the last, we using the ROCcurve, Sen as the length coordinate and the1-Spe as the breadth coordinate, accordingthe abnormal is coronary stenosis≥50%, then the best point of BIF-IMT is0.95mm(Sen0.873;Spe0.667); the area under ROC curve was0.739.Then according theabnormal is coronary stenosis≥75%, the best point of BIF-IMT is2.35mm; the AUCis0.704(P<0.01).Conclusion The method of divided by different IMT can provide reference value forthe level of stenosis and whether to need to take the CAG...