Association And Interaction Analysis Of Metabolic Syndrome And Serum Uric Acid On Diastolic Heart Failure

Objective: To assess the extent to which metabolic syndrome (MetS) and serumuric acid (UA) and its interaction impact on diastolic heart failure (DHF).Methods: A total of133patients with DHF and118age-and gender-matched controlsubjects were studied. Echocardiography was used to assess left ventricular(LV)diastolic function. MetS was defined by suggestions of international diabetesfederation (IDF,2005). The association between MetS or UA and DHF was assessed bymultivariate logistic regression analysis (MLR) controlling confounders. Theinteraction between MetS and UA on DHF was assessed by generalized linear model(GLM) and MLR analysis.Results:1.In the present study, BMI, SBP, DBP, FPG, postprandial blood glucose (PBG),and lipid and lipoprotein profile were not significantly different between DHF groupand control group(p>0.05), while serum UA was significantly greater(p<0.001). LAD,DT and LVMI were greater in cases compared with controls (p<0.05).2.The univariate analyses indicated that variables of LAD, LVMI, DM, HP, UAand MetS were significantly associated with DHF(P <0.05for all), respectively. MetSand UA remained significant differences between DHF and non-DHF group afteradjustment for age, gender, smoking, and echocardiography parameters (P <0.05, data not shown). MetS and UA were independent predictors of DHF after adjustment for allvariables(ORMetS=0.833~2.27, ORUA=1.003and P <0.05for all). There was aninteraction effect of MetS and UA on DHF (ORMetSbyUA=2.41~2.66, PInteraction<0.05).Conclusion: The findings of the present study suggested that MetS or UA is associatedwith DHF, and that MetS interacts with UA to impact on DHF.