The Diagnosis Value And Clinical Significance Of Serum Golgi-protein73in Patients With Primary Hepatic Carcinoma

Objective：To explore the diagnostic value and clinical significance of Golgiprotein-73（GP73）in patients with primary hepatic carcinoma (PHC). Methods：80PHC,65liver cirrhosis,54chronic hepatitis patients and50controls were selected.GP73wasdetected by ELISA and AFP was measured by clinical chemiluminescence. The sensitivity,specificity and area under ROC curve of each parameter were evaluated. The relationshipbetween GP73expression and clinical parameters was also analyzed. Results：1. SerumGP73in PHC group282.0（163.6～366.7）μg/L, was higher than that in liver cirrhosisgroup211.8（107.5～295.7）μg/L, chronic hepatitis group100.3（61.8～191.3）μg/L andcontrol group58.3（43.4～83.6）μg/L（P <0.01）.2. In diagnosis of PHC, the sensitivityof GP73[82.5%(66/80)] was higher than AFP [66.3%(53/80), P<0.05], but itsspecificity [63.3%(107/169)] was lower than AFP [88.7%(150/169), P<0.05]. Thesensitivity of GP73and AFP in combining form90%was higher than AFP66.3%.3. Indiagnosis of early stage PHC, the sensitivity of GP73[72.5%（29/40）] was higher thanAFP [50.0%（20/40), P<0.05], but its specificity [70.4%(81/115)] was lower than AFP[95.7%(110/115), P <0.05].4. The positive rate of GP73in diagnosis of AFP negativePHC was [81.5%(22/27)].5. Patients in early stage PHC, GP73in Child C group365.2(351.8～370.8) μg/L was higher than that in Child B group310.6(183.3～380.1)μg/L and Child A group176.6(109.0～241.5) μg/L, P=0.002; patients with liver cirrhosis,GP73in Child B group307.3(139.1～397.7) μg/Lwas higher than that in Child A group176.6(109.0～241.5) μg/L, P>0.0083.6. Serum GP73expression was correlated with livercirrhosis, vascular invasion and clinical TNM staging (correlation coefficient r was0.27,0.29,0.27, all P <0.05); but not with sexuality, age, AFP>13.4μg/L, tumor size and distantmetastasis (correlation coefficient r was0.13,0.10,0.03,0.18,0.04, all P <0.05).Conclusions：GP73and AFP have a complementary feature of sensitivity and specificityin the diagnosis of PHC, the sensitivity can be further elevated in the combining form, some PHC cases with AFP negative can avoid being missed efficiently. GP73has a goodsensitivity in the diagnosis of both early stage PHC and AFP negative PHC. The rise ofserum GP73might be correlated with liver tumor load and tumor aggression, and itsbiological characteristics requires more researches to verify.