A Literature-based Analysis On Herbal Administration Regularity Of Insomnia And The Clinical Study

Objective: To explore the TCM differential treatment regulation of insomnia, in orderto the main pathogenesis of insomnia and develop the prescription in treating insomnia.Then, we established a clinical randomized controlled trial to observe the clinical curativeeffect of the prescription, and prove the value of the literature research. Methods: Firstly,the literature research collected from Chinese journal full-text database (1994-2011),analysis has been carried out deeply; focus on the laws of medicine that had been used,especially the decoction medicine. At the same time, we pursued the main pathogenesisand treatment for insomnia. Secondly, we did clinical study to verify its efficacy. Databasewas established with Excel software, the medicine served as the variable, the medicinefound in prescriptions was valued as1, the medicine absence in prescriptions was valuedas0. Frequency analysis was applied to find the commonly used medicines and medicinecategory, clustering analysis was applied to find the prescription their components withclose interrelationship, all above methods were been used to explore the regulations ofChinese herbs usage and the main pathogenesis and the treatment prescription for insomnia.Next, we established a clinical randomized controlled trial to verify its efficacy and provethe value of the literature-based study. Results:251papers were selected out from theperiodical database according to the inclusion criteria and the exclusion criteria; there aretotal172kinds of Chinese herbs. The total frequency was2701times. The most frequentlyused drug was tonic drugs, their frequency was above25percent. The frequency ofsedative drugs was above24percent, only second to the tonic drugs. The three kinds of significant medicine property are flat, cold and warm. The three kinds of herbal taste ofsweet, bitter and Xin are most commonly used. Drugs were classified by meridian; the topfive are the heart, the liver, the spleen, the kidney and the lung. The clinical trial resultsshowed: the treatment group and the control group had no significant difference in thePSQI score before and after treatment and the overall effect of sleep quality, but hadobvious difference in the total effect of insomnia. Conclusions:1.Based on the analysis ofInsomnia prescription of Chinese medicine treatment, Semen zizyphi spinosae, Radixliquiritiae and Caulis polygoni multiflori are most commonly used. The most frequentlyused drug classes are tonic drugs and sedative drugs. The property of herbs is mainly flat,cold and warm. The tastes is mainly sweet, bitter and Xin, meridians mainly the heart andthe liver.2. Insomnia medication is mainly the tonic medicine, followed by eliminating evildrug. Thereinto, the tonic is mainly nourishing the heart and liver blood, and theeliminating evil drug is mainly regulating qi-flowing for eliminating phlegm.3. The mainpathogenesis of Insomnia is the heart and liver blood deficiency, qi stagnation and phlegmstagnation. The treatment shoud be nourishing the blood and tranquilization, regulatingqi-flowing for eliminating phlegm. The representative prescription is Jiawei Sini Decoction.4. The Jiawei Sini Decoction has significant effect on the Insomnia, no less favorable thanthe Suanzaoren Decoction. The literature-based research has high clinical value.