Study On The Correlation Between Serum Visfatin, Adiponectin And Carotid Atherosclerosis

ObjectiveVifatin and Adiponectin were novel adipokines mainly produced by visceralfat. They were closely related to atherosclerosis. This experiment explored thecontribution of serum Visfatin and Adiponectin in the atherosclerosisprogression through studying their levels in patients of different intima-mediathickness and carotid atherosclerosis nature and their relationships to lipid,glucose and pressure.MethodsThe study was designed in the affiliated hospital of Taishan MedicalUniversity from June2011to June2012. The patients with cerebral infarctionand carotid artery atherosclerosis served as case groups:54male and36female.36subjects matched by age and gender who made health examination in thehospital served as controls:18male and12female. All subjects were recordedthe records of the carotid artery ultrasound, past medical history, personalhistory and family history. A single blood sample was obtained after overnightfasting. Serum adiponectin, Visfatin and fasting insulin were measured byenzyme linked immunosorbent assay(ELISA), whereas total cholesterol(TC),triglycerides(TG), high density lipoprotein(HDL), low density lipoprotein(LDL),and fasting plasma glucose(FPG) were measured by automatic biochemistryanalyzer. All statistical analysis were performed using the Statistical Packagefor Social Science(SPSS for Windows, Version17.0).Results1. Serum Visfatin was significantly higher in carotid atherosclerotic plaquegroups compared to the normal controls (P<0.05). The Visfatin level in low echogroup was higher than mixed echo group (P<0.05). The Visfatin level in mixed echo group was higher than strong echo group and low echo group (P<0.05). TheVisfatin level in unstable plaque group was higher than stable plaque group(P<0.05).2. Serum Adiponectin was significantly lower in carotid atheroscleroticplaque groups compared to the normal controls (P<0.05). The Adiponectin levelin low echo group and mixed echo group were lower than strong echo group(P<0.05). Adiponectin level in unstable plaque group was lower than stableplaque group (P<0.05).3. Serum Visfatin was significantly higher in carotid artery intima-mediathickness groups compared to the normal controls (P<0.05). The Visfatin levelin1.1≤ITM＜1.2group was higher than1.0≤ITM＜1.1group and0.9≤IMT＜1.0group (P<0.05). The Visfatin level in1.0≤ITM＜1.1group was higher than0.9≤IMT＜1.0group (P<0.05).4. Serum Adiponectin was significantly lower in carotid artery intima-media thickness groups compared to the normal controls (P<0.05). Theadiponcein level in0.9≤IMT＜1.0group and1.0≤ITM＜1.1group were higherthan1.1≤ITM＜1.2group (P<0.05).5. The Visfatin level was positively and significantly correlated with TG,FPG, LDL, DBP, IMT (P<0.01), and was negatively and significantly correlatedwith HDL (P<0.01), and was no correlated with age in patients with carotidatherosclerotic plaque groups.6. The adiponectin level was negatively correlated with TG, FPG, LDL,SBP, DBP, IMT (P<0.05), and was positively and significantly correlated withHDL (P<0.01), and was no correlated with age in patients with carotidatherosclerotic plaque groups.7. In multiple regression analysis, LDL, FPG, TG were associated withVisfatin, whereas HDL, TG were associated with adiponectin.Conclusions1. Increased Visfatin expression has been found in unstable plaque group,so it reduced stability of plaque. The Adiponectin level in the stable plaquegroup was higher than the unstable plaque group, so it increased stability ofplaque.2. High-level Visfatin and low level Adiponectin could cause increased carotid artery intima-media thickness.3. Visfatin and adiponectin may play an important role in the developmentand progression of atherosclerosis by participating in pressure, glucose and lipidmetabolism, and inflammation.