| Objective: With the aggravation of the aging trend, changes of people’s life style,such as the intake of high-calorie, high fat food increased and decreased physicalactivity and other reasons, the prevalence rates of essential hypertension(EH) andosteoporosis(OP) increased year by year. We used to think that the two are independentdiseases, in fact, they usually occured simultaneously, especially in postmenopausalwomen, osteoporosis patients often complicated with hypertension, but the correlationbetween the two was still controversial. The objective of this paper was to study andexplore the relationship between these two deseases in postmenopausal women.Methods: During the period of August16th to December10th，2011.10300community residents aged no less than40-year-old accepted the Chinese type2diabetesrisk for cancer epidemiology investigation of Dalian area. We measured their bloodpressure, pulse rate, height, weight, waist circumference, hip circumference, calculatedthe pulse pressure, body mass index(BMI) and waist-hip-ratio(WHR), and detected thelumbar spine1-4(L1-4) bone density of T scores(BMDTs), fasting plasma glucose,postprandial2hour plasma glucose, three glycerol(TG), total cholesterol(TC), highdensity lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C)and other indicators. According to the inclusion and exclusion criteria,715cases werecollected in accordance with the standard, and they were divided into two groupsaccording to the diagnostic criteria of osteoporosis approved by WHO: Normal bonemass group, Osteopenia group and Osteoporosis group, to compare the three groups ofdata of the blood pressure, and analyze the correlation between blood pressure andBMDTs of the lumbar spine.Results:1.The prevalence rate of hypertension of Normal bone mass group,Osteopenia group and Osteoporosis group were (32.0%vs37.3%vs46.4%), thedifference was statistically significant(χ2=7.182, P=0.028), the prevalence rate of hypertension of Osteoporosis group was significantly higher than that of Normal bonemass group(χ2=6.904, P=0.009), the prevalence rate of hypertension of Osteopeniagroup and Normal bone mass group had no statistically significant difference(χ2=1.901,P=0.168), the prevalence rate of hypertension of Osteopenia group and Osteoporosisgroup had no statistically significant difference(χ2=2.451, P=0.117).2. Systolic blood pressure of Osteoporosis group, Osteopenia group and Normalbone mass group were respectively(139.24±20.63vs137.22±21.13vs132.23±18.77)mmHg, there were significant differences between the three groups(F=6.010,P<0.05), systolic blood pressure of Osteoporosis group was significantly higher thanthat of Normal bone mass group(P<0.05), systolic blood pressure of Osteopenia groupwas significantly higher than that of Normal bone mass group(P<0.05), and there wasno significant difference of systolic blood pressure between Osteoporosis andOsteopenia group(P>0.05), the pulse pressure of Osteoporosis group, Osteopenia groupand Normal bone mass group were respectively(61.14±18.62vs58.36±16.54vs54.50±14.80)mmHg, there were significant differences between the three groups(F=6.944,P<0.05), pulse pressure of Osteoporosis and Osteopenia group was significantly higherthan that of Normal bone mass group(P<0.05), there was no significant differencebetween Osteoporosis and Osteopenia group(P>0.05), diastolic blood pressure of thethree groups was not significantly different(P>0.05).3. Systolic blood pressure was negatively correlated with Avg-BMDTs of thelumbar spine(r=-0.117, P=0.002), there was no correlation between DBP andAvg-BMDTs(r=0.003, P=0.946), pulse pressue was negatively correlated withAvg-BMDTs (r=-0.144, P=0.001).4. With age, height, weight, BMI, hip circumference, HDL-C, TG, systolic bloodpressure, diastolic blood pressure, pulse pressure as independent variables, thesignificant level of0.05, Avg-BMDTs of the lumbar spine as dependent variable formultiple stepwise linear regression analysis, age, BMI, systolic blood pressure, TGentered the equation(r=0.284, r2=0.081), the age was negatively correlated withaverage BMDTs(β=-0.033, P<0.01), BMI was positively correlated with averageBMDTs(β=0.060, P<0.01), TG was positively correlated with average BMDTs(β=0.270,P<0.01), and systolic blood pressure was negatively correlated with averageBMDTs(β=-0.008, P<0.01).Conclusion:1. Postmenopausal women with osteoporosis and osteopenia havehigher SBP. 2. Bone mineral density in postmenopausal women decreased may be associatedwith hypertension, and systolic blood pressure is negatively correlated with bonemineral density, systolic blood pressure is an independent risk factor for osteoporosis. |
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