Causes Of Stopping Subcutaneous Specific Immunotherapy In Asthmatic Children And Their Current State Report

PART ICAUSES OF STOPPING SUBCUTANEOUS SPECIFICIMMUNOTHERAPY IN ASTHMATIC CHILDRENObjective: To improve the compliance with subcutaneous specificimmunotherapy (SCIT) by analyzing the causes of stopping SCIT inasthmatic children.Methods: A telephone follow up was conducted in the asthmaticchildren who received SCIT but did not finished the3-year course of thetreatment from June2005to October2010,so as to analyze the causes ofstopping SCIT.Results: A total of616asthmatic children received SCIT, and322cases (52.2%) of them stopped SCIT.A total of127cases (39.3%) of the322children received telephone follow up. In the127children,53(41.8%)stopped the SCIT for the reason of bad efficacy,29(22.8%) for remission ofasthma,12(9.4%) for expensive fees,10(7.9%) for complex process of SCIT,10(7.9%) for adverse reaction,9(7.1%) for long distance from hospital,and4(3.1%) for having no time for treatment. And69(54.3%) of themstopped SCIT in the first year,28(22.1%) in the second year, and30(23.6%)in the third year.Conclusion: Bad efficacy, remission of asthma, expensive fees,complex process of treatment, and adverse reaction are the main reasoncontributing to the stop of SCIT in asthmatic children. To improve thecompliance with SCIT, it is important to make patients and their parentsunderstand the long treatment course and slow effect of SCIT, encouragethem to use objective indices for evaluating the state of asthma, andeffectively prevent and treat the adverse reactions. PART ⅡCURRENT STATE OF ASTHMATIC CHILDRENSTOPPING IMMUNOTHERAPY AND ITSINFULUENCING FACTOURSObjective: To investigate influencing factors of the level of asthmacontrol in children stopping specific immunotherapy.Methods: A telephone follow up was conducted in the127asthmaticchildren who received SCIT but did not finished the3-year course oftreatment from June2005to October2010.All asthmatic children weredivided to two groups (the controlled and the uncontrolled) based on theirlevel of asthma control. Nine factors, such as gender, age, family history ofallergic diseases, level of mite allergy, times of SCIT, causes of stoppingSCIT, whether inhaling corticosteroids regularly, adverse reaction of SCITand asthma with rhinitis or not, were analyzed with software SPSS18.0.Results: The average age of these127asthmatic children was7.8+3.8years. The proportion of boys and girls was87/40.In the127Children,85(66.9%) got controlled, whereas42(33.1%) did not. In the9factors, familyhistory of allergic diseases (P=0.035), causes of stopping SCIT (P=0.000),whether inhaling corticosteroids regularly (P=0.007) are significantlyrelated to prognosis of asthma. Thus, age of these asthmatic children, levelof mite allergy, times of SCIT, adverse reaction of SCIT and asthma with rhinitis or not, are not related to the level of asthma control.Conclusion: Stopping SCIT may reduce the ratio of asthma control.Family history of allergic diseases, whether inhaling corticosteroidsregularly, are important factors affecting the prognosis of asthma.Assessment of clinical efficacy of SCIT may predict prognosis of asthmaticchildren stopping specific immunotherapy with standardized house-dustmite extract.