1、An Analysis Of Skin Prick Test Reactivity To Dust Mite In Overweight And Normal-weight Children With Allergic Asthma Before And After Specific Immunotherapy 2、Analysis Of The Skin Index Of Non Dust Mites In Childhood Allergic Asthma Before And After

Objective To analyze the skin prick test(SPT) of house dust mite allergens in overweight and normal-weight children with allergic asthma before and after standard subcutaneous specific immunotherapy. Methods Two hundred and fifteen children with allergic asthma who had positive SPT responses to Dermatophagoides pteronyssinus and Dermatophagoides farinae were enrolled as subjects. According to the weight index, they were divided into overweight group(n = 63) and normal group(n = 152). Between-group comparison of skin indices(SI) to Dermatophagoides pteronyssinus and Dermatophagoides farinae was performed before and at 6 months and 1 year after standard subcutaneous specific immunotherapy. Results Before treatment, the overweight group had a significantly larger histamine wheal diameter than the normal group(P <0.05); there were no statistical differences in SI to Dermatophagoides pteronyssinus and Dermatophagoides farinae between the overweight and the normal group(P >0.05). At 6 months and 1 year, the SI to Dermatophagoides pteronyssinus and Dermatophagoides farinae were reduced in both groups significantly(P <0.05); the histamine wheal diameter remained the same in both groups; the overweight group had a larger decrease in the SI to Dermatophagoides pteronyssinus and Dermatophagoides farinae than the normal group. Conclusions The overweight children with allergic asthma have stronger responses to histamine than the normal-weight patients. Specific immunotherapy can reduce the reactivity to dust mite allergens. Within one year after specific immunotherapy, the overweight children with allergic asthma have a significantly larger decrease in the reactivity to dust mite allergens than the normal-weight patients.Objective: To study the nonspecific immune effect in dog hair, cat hair, cockroaches, cigarettes, pollen, mold, ragweed and Artemisia, of dust mites allergen subcutaneous specific immunotherapy in childhood allergic asthma. Methods: 172 cases of allergic asthmatic children from our hospital enrolled in this study. The skin prick test was positive. We compared the skin index(SI) of dust mites, dog hair, cat hair, cockroaches, cigarettes, pollen, mold, ragweed and Artemisia,the histamine wheal size, before and after 6 months and 1 year specific immunotherapy. Results: The dust mites SI was lower after treatment significantly(P<0.01), also, the dog hair, cat hair, cockroaches, cigarettes, pollen, mold, ragweed and Artemisia SI declined and turn negative( P<0.05).But the histamine wheal size did not decline(P>0.05). Conclusions: The dust mites allergen subcutaneous specific immunotherapy could not only reduce the allergic intensity of dust mite, but also had nonspecific immune effect in dog hair, cat hair, cockroaches, cigarettes, pollen, mold, ragweed and Artemisia.