Relationship Between Glycated Hemoglobin Levels In Diabetes Mellitus And Obstetric Complications Of Pregnancy

Objective: For pregnant women to carry on the strict glycemic control in diabetesdiagnosis, research on HbA1c levels and premature birth, polyhydramnios,macrosomia, premature rupture of fetal membrane, fetal distress, neonatalhypoglycemia, and the relationship between the incidence of cesarean section, etc,and to discuss changes in blood glucose control before and after the HbA1c’srelationship with the incidence of complications.Methods: Collected during sep2012-June2013, shenyang penetration hospitalmaternity clinics,24to28weeks of gestation diagnosis of gestational diabetes women,system control blood sugar and continue to track to terminate a pregnancy, the casesof data collection. Line twice glycosylated hemoglobin HbA1c measurement (assayfor the diagnosis of gestational diabetes for the first time the next day, two times forthe termination of pregnancy before the next day after admission), compare differentHbA1c levels and changes in HbAc1and the relationship between the incidence ofpregnancy complications.Results:①The GDM group was significantly higher than that in maternalprepregnancy weight, family history monthly income, diabetes control group; groupGDM BMI in the range of24.0-28.0is higher than those of control group; GDMgroup living in rural areas the highest constituent ratio, the control group living in thecity the highest constituent ratio; two groups in the aspects of occupation. There wereno significant differences in.②The GDM in group HbA1c were significantly higherthan the control group, the level of HbA1c′termination of pregnancy before theGDM group were significantly higher than control group, P <0.05. Two groups of thesystem control of blood glucose, termination of pregnancy before the HbA1c′levels were significantly lower than the group level, P <0.05.③In group GDM,HbA1c′=6.5%the incidence of premature delivery, polyhydramnios, incidenceof macrosomia rate, the incidence of fetal distress, neonatal hypoglycemia, the rate ofcesarean section were significantly lower than those of HbA1c′>6.5%, but higherthan that of the control group, P<0.05. HbA1c ’level does not affect the incidence rateof premature rupture of membranes.④Compared with the baseline HbA1c levels,HbA1c increased in preterm delivery rate, too much amniotic fluid, distress, the incidence rate of cesarean section was significantly higher than that of HbA1cinvariant and HbA1c in GDM group decreased, increased, decreased, unchanged fetus,P <0.05; the incidence of macrosomia, premature rupture of membranes, theincidence of newborn the incidence of hypoglycemia is not affected by changes inHbA1c levels, P>0.05.Conclusion:1.GDM pregnant women’s income level, pre pregnancy weight, diabetes familyhistory of diabetes were higher than those in non pregnant women with GDM;2.High levels of HbA1c GDM in pregnant women, premature occurrence rateincreased;3.GDM HbA1c levels in pregnant women, polyhydramnios, fetal distress obstetriccomplications incidence rate also increased;4.GDM HbA1c levels in pregnant women, neonatal hypoglycemia, macrosomia raterise height;5. GDM of pregnant women with blood glucose control, HbA1c decreased, cansignificantly reduce the incidence of premature delivery, obstetric complications, fetalmacrosomia, neonatal hypoglycemia etc..