The Clinical Significance Of High Mobility Group Protein B1in Plasma Of Patients With Acute Coronary Syndromes

Objective: To discuss the correlation between concentration of High MobilityGroup Protein B1in peripheral blood and coronary lesions in patients with acutecoronary syndromes.Method：93patients who did the examination of coronary arteriography inDepartment of Cardiovascular Medicine of the Second Affiliated Hospital of DalianMedical University from August to December2012were chosen. In accordance withthe clinical manifestation and laboratory examination, all patients were divided into twogroups. One is ACS group (63patients), and another is Normal group (30patients).ACS group contains UAP group(32patients) and AMI group(31patients). All thepatients did the examination of coronary arteriography. According to the Gensini scoreof coronary lesions, ACS group(N=63)was divided into group A(1≤Gensini score＜20points,18patients),group B(20≤Gensini score＜40points,28patients)and groupC(Gensini score≥40points,17patients). We used ELISA to detect the concentration ofHMGB1in plasma of patients. Then we discussed the correlation between the changesof concentration of High Mobility Group Protein B1and Gensini Grade. We usedSPSS17.0to make statistical processing. P<0.05have statistically significant.Result:1.The level of HMGB1was significantly higher in AMI group than inUAP group(6.38±3.47vs.4.05±1.86，P<0.01); The level of HMGB1was significantlyhigher in UAP group than in Normal group(4.05±1.86vs.3.14±0.98，P<0.01).2. The level of HMGB1rose with the exacerbation of coronary lesions accordingto the Gensini Grade(3.27±1.43vs.4.62±1.93vs.8.18±3.46，P<0.05). Each group wasstatistically significant. According to the examination, a positive correlation wasdetected between the level of HMGB1and the severity of coronary lesions(r=0.366，P<0.05). Conclusion: The level of HMGB1in patients with acute coronary syndromeincreased significantly. And it has the positive relationship with the severity of coronarylesions. The more serious of the damage, the more significantly HMGB1increased. SoHMGB1might be closely associated with the occurrence of Acute Coronary Syndromeand the severity.