Relationship Of PSA And Gleason Score,Clinical Stage In Prostate Cancer

To investigate the relationship among serum prostate specific antigen (PSA), Total PSA (TPSA), free-to-total PSA ratio (f/t PSA), PSA density (PSAD), Gleason score and clinical stage in men with prostate cancer.Methods:A retrospective study analysis was done for87patients of prostate cancer confirmed pathologically by prostate biopsy at our department from Jan2011to Dec2012. TPSA, f/t PSA, PSAD, Gleason score and clinical stage were obtained and analyzed using Spearman rank correlation and logistic regression.Results:When serum TPSA>10ng/ml, TPSA (r=0.393, P<0.01) and PSAD (r=0.424, P<0.01) increase, whereas f/t PSA decreases (r=-0.373, P<0.01) with increase in Gleason score. Patients with higher clinical stage have higher TPSA level (r=0.759, P<0.01), higher PSAD level (r=0.753, P<0.01) and higher Gleason score (r=0.244, P<0.01), but lower f/t PSA level (r=-0.393, P<0.01) when serum TPSA>10ng/ml. TPSA is a major factor to predict Ⅲ and Ⅳ stages of patients with prostate cancer (OR=1.039, P<0.05).Conclusions:When serum TPSA>10ng/ml, TPSA, PSAD level are positively correlated with Gleason score for patients with prostate cancer, whereas f/t PSA is negatively correlated with Gleason score. Positive correlations between TPSA, PSAD, Gleason score with clinical stage and a negative correlation between f/t PSA and clinical stage are demonstrated when serum TPSA>10ng/ml. TPSA could predict the stages of patients with prostate cancer.