Meta-Analysis Of Curative Effect Of Traditional Chinese Medicine Combined With Chemotherapy In Treating The Advanced Gastric Cancer

Background:Gastric cancer is one of the commonest malignancy, and its incidence rate and the mortality rate are on the rise in recent years. Gastric cancer has already taken the first place of various malignancy in many of our large and medium-sized cities. Because there are few specificities in clinical symptoms of Gastric cancer and the corresponding clinical examination indicators are not sensitive, most of the gastric cancer patients were belonged to later period when they see a doctor, and they have already lost the opportunity to be cured by surgery.For the moment, doctors usually adopt complex treatment to treat patients of gastric cancer, including Radiotherapy, chemotherapy, immune therapy, Chinese medicine treatment and support treatment method, etc, at present still with chemotherapy as a preferred solution, But the overall curative effect were unsatisfactory. A lot of research reveals that TCM has certain advantages in increases the effectiveness of the chemotherapy, improving their life qualities and prolong survival. Therefore treating advanced gastric cancer with Traditional Chinese medicine and chemotherapy is being emphasized by clinical oncologist and warrants further investigation.Obiectives:This research will summarize the research literatures in2008-2012,which is about the effect of TCM combined with chemotherapy on treating the advanced gastric cancer and also take the chemotherapy group as the comparison group and make Meta analysis. The study aim to compare the curative effect of Traditional Chinese medicine combined with chemotherapy and chemotherapy alone in patients with advanced gastric cancer through Meta analysis.Methods:This research analyzes the method with Meta to come to the Traditional Chinese medicine combined with chemotherapy in the advanced gastric cancer curative effect to carry on the appraisal. Carries on the comprehensive retrieval according to the hypothesisretrieval way, after bring into line with removes the standard to determine the selected literature, carries on the literature quality appraisal with the Jadad meter, carries on the data to the selected literature research the input, Review Manager v5.2software carries on the statistical data analysis using RevMan, and carries on the publication bias analysis and the sensitivity analysis.Results:This research has altogether bought into line with in16recent years related Traditional Chinese medicine combined with chemotherapy treatment the advanced gastric cancer and makess the comparison with the chemotherapy alone the RCT research, used the Meta analysis the method the advanced gastric cancer curative effect to carry on the analysis to the Traditional Chinese medicine combined with chemotherapy treatment in:the Traditional Chinese medicine combined with chemotherapy group is opposite to the chemotherapy alone group, The disease control rate:RR=1.35,95%confidence interval (1.15,1.60); The clinical benefit rate: RR=1.21,95%confidence interval (1.11,1,31); the improve the quality of life rate: RR=1.88,95%confidence interval (1.59,2.21); the Quality of life stability rate: RR=1.35,95%confidence interval (1.24,1.46); The3year survival rate:RR=2.35,95%confidence interval (1.52,3.65)=Conclusion:1. The disease control rate and the clinical benefit rate, TCM combined with chemotherapy group were higher than that of simple chemotherapy group, the results further demonstrate the synergistic effect of Chinese medicine on chemotherapy.2. the quality of life improve rate and the quality of life stability rate, TCM combined with chemotherapy group were higher than that of simple chemotherapy group, proved that TCM has significant effect in improving the quality of life of the patients.3. Traditional Chinese medicine combined with chemotherapy group in the3years survival rate has certain advantages.