The Value Of Gelatin Sponge Particles In TACE Treatment Of Massive Hepatocellular Carcinoma

Objective: Primary hepatic carcinoma is one of the most commonmalignant tumor in our country, The preferred method of treatment ofearly liver cancer is surgical excision. But the most common clinical livercancer is terminal-stage one. Most of them have lost the chance ofoperation. Especially for massive hepatocellular carcinoma, There is greatdifficulty and surgical high risk, and there will be a lot of post-operativecomplications and high mortality. In recent years, Transcatheter hepaticarterial chemoembolization(TACE) has become the main method oftreatment in patients with advanced hepatocellular carcinoma, Especiallyof the massive hepatocellular carcinoma. The basic principle for theTACE as follows. The hepatic artery embolization blocks tumor bloodsupply, to control tumor growth and let tumor necrosis even shrink,however, there is little effect on normal liver tissue. the efficacy of TACEwill be affected by the choose embolic agent used in surgery.Methods: This paper selects56cases of massive hepatocellularcarcinoma patients from January2012to August2012as the researchobject. Depending on the application of intraoperative embolization intopure iodized oil emulsion embolization group (group A,22cases),iodized oil emulsion gelatin sponge particles embolization group (group B,34cases). All patients were in line with HCC clinical diagnosticcriteria, and identified as the first-line treatment of TACE. Before andafter operation, all routine to do a-fetoprotein (AFP), liver function, liverCT examination. Comparative analysis of the two sets of patient data.Result:1. One month after surgery, patients in group B compared with group A,AFP values decreased more significantly. The difference was statisticallysignificant(P<0.05);2. One month after surgery, patients in group B compared with group A,CT scans intralesional iodized oil deposition effect is more real(P<0.05);3. One week after surgery, the two groups were not statisticallysignificant changes in transaminases after one week (P>0.05);4. After surgery all patients had varying degrees of adverse reactions.patients in group B had a greater chance of postoperative adversereactions.Conclusions: The results suggest that the addition of gelatin spongeparticles TACE treatment of massive hepatocellular carcinoma iseffective. AFP significant decrease occurred, and deposition was better.Liver function after1week was no significant difference compared withpure iodized oil embolization group. There was no more aggravated liverdysfunction. But there is likely to increase the chance of postoperativeadverse reactions. Since the application time of the clinical application of gelatin spongeparticles is shorter, this study is only a short follow-up of patients. Itseffect in the technique with conventional need long time of study. Beforelong a large sample study results appear, this article only on theapplication of the gelatin sponge particles with conventional surgery, andachieved good short-term clinical curative effect, provide a clinical basis.