The Efficacy And Safety Of Anticoagulation Therapy By Warfarin Sodium And Dabigatran Etexilate In Patients With Non-valvular Atrial Fibrillation

ObjectiveThis is an evaluation of Warfarin Sodium and dabigatran etexilate in patients With non-valvuar aratrial fibrillation(NVAF).Methods31patients received Warfarin Sodium treatment,specific measurement according to patients condition adjustment.23Patients received two doses of150-mg or110-mg dabigatran etexilate respectively twice daily. The median duration of the follow-up Period was6months. The safety end Points were hemorrhage, Serious liver (?)icity,creatinine clearance rate significantly degrade.ResultWarfarin sodium recipients occurred two stroke and one died,at the same time there were five cases of small bleeding.Dabigatran recipients occurred one stroke and one case of small bleeding. This study observe the effects on blood pressure, heart rate,blood lipids,blood uric acid, renal and liver function of warfarin sodium and dabigatran etexilate.The two indicators had an increase within the normal range.serious liver or renal toxicity was not seen.ConclusionsWarfarin Sodium and dabigatran etexilate had no significant effect on the internal organs,its safety and reliable.