Efficacy And Safety Of Dabigatran Etexilate In Anticoagulant Therapy After PCI Operation Of Patients With Atrial Fibrillation And Coronary Heart Disease

Objective research the effectiveness and safety of using Dabigatran Etexilate-one of the Non-vitamin K dependent oral anticoagulants after PCI operation of atrial fibrillation and coronary heart disease during anticoagulant therapy.Analyze whether it can be an ideal choice for anticoagulation therapy after atrial fibrillation combined with PCI operation.Methods select patients,and divide them into observation group and comparison group randomly.Each group contains 45 persons.Observe them to take 110 mg Dabigatran Etexilate twice everyday orally.Treat the comparison group with Warfarin,and adjust the INR within 2.0-3.0.In the meantime,every day let the two groups to take 100 mg aspirin.Observe and make follow-up visit for 12 months,and compare the laboratory index including Platelet Count,Fibrinogen,D-Dimer,CRP change,neopathy acute myocardial infarction,acute cerebral infarction,and embolism in non-central nervous system,bleeding and the occurrence rates of other adverse reactions between two groups.The statistical data were expressed as mean ± standard deviation(± s),the independent samples t-test and paired t-test were used for comparison between groups.The count data was expressed as n(%),and the comparison between groups was performed by chi-square test Efficacy and Safety of Group Esters in Anticoagulation Therapy.Results the occurrence rate of using Dabigatran Etexilate to treat embolism in central nervous system is lower than that in Warfarin group,however,there is no statistical significance;meanwhile,the occurrence rate of bleeding in Dabigatran Etexilate group is lower than that in Warfarin group(P=0.036);no significant difference has been shown on the occurrence rate of adverse reactions.Conclusion In the anticoagulant therapy of patients with atrial fibrillation and coronary artery disease after PCI,the efficacy of dabigatran etexilate reached the level of traditional oral anticoagulant drugs,and was more superior in reducing the serious dangerous events such as cerebral hemorrhage and gastrointestinal bleeding Traditional oral anticoagulants.Have higher clinical value,in such patients anticoagulation therapy is worth applying.