Correlation Studies Of TAP1,FOXJ1Gene Polymorphism With Autoimmune Thyroid Disease

Objective: Analyze the distribution of TAP1，FOXJ1gene polymorphism in ShanxiHan population of patients with autoimmune thyroid disease， and explore itsrelationship with autoimmune thyroid disease susceptibility， so as to provide ascientific basis for screening of autoimmune thyroid diseases high-risk groups， andto seek for the hyperthyroidism，autoimmune thyroid diseases such as hashimoto’sdisease occurrence and development mechanism provides a new train of thought，provide new way for treatment ofAITD.Methods: By PCR-RFLP method，this paper discusses the TAP1-rs1057141A>G，FOXJ1-rs1868823G> T loci of genotype distribution and the relationship ofsusceptibility whih GD and HT in89Shanxi Han AITD patients (44cases of GDgroup，45cases of HT group) and40cases of normal control group.Results:①TAP1-rs1057141A>G site AA、GG and AG genotype frequency in theGD group were60%，4.4%and35.6%，respectively，in HT group were52.3%，2.3%and45.5%，while in the control group were57.5%，17.5%and25%，respectively.Aand G allele frequency in GD group、HT group and the control group，respectively77.8%，22.2，75%，25%，70.0%，30.0%. In this experiment genotypes are givenpriority to with AA type， allele is given priority to with A; The AA genotypefrequency is consistent in the HT group and the control group， and GD slightlyhigher than the HT group and the control group. By chi-square test，TAP1-rs1057141A> G genotype frequencies in the GD group and the control group was notstatistically significant (χ2=5.398，P=0.247)，in the HT group and the controlgroup between the two groups also no statistically significant (χ2=10.526，P= 0.031).②FOXJ1-rs1868823G> T loci GG，TT and GT genotype frequency in theGD group were42.2%，6.7%and51.1%，respectively，in the HT group were54.6%，2.3%and43.2%， respectively， in the control group were60.0%，20.0%and20.0%respectively. G，T allele frequency in GD group、HT group and controlgroup were67.8%，32.2%，76.1%，32.2%，70.0%，30.0%. In GD is given priorityto with GT type，and in the HT group and the control group is given priority to withthe GG type. GD group compared with the control group，the distribution of threekinds of genotype frequency was statistically significant (χ2=9.950， P=0，040))，HT group and the control group also statistically significant (χ2=10.526， P=0.031).③The risk analysis of TAP1-rs1057141A> G gene polymorphism and GDshowde that compared with AA genotype，GG genotype OR=0.243(95%CI=0.046-1.289)，andAG genotype OR=1.363(95%CI=0.5193.682)，the analysis inthe HT， GG genotype OR=0.143(95%CI=0.0161.256)，AG genotype OR=2.000(95%CI=0.7705.193). The risk analysis of FOXJ1-rs1868823G> T genepolymorphism and GD showde that compared with GG type，GT type OR=3.632(95%CI=1.3309.918)，TT type OR=0.474(95%CI=0.1102.034)，and in HT，GT type OR=2.375(95%CI=0.8736.646)，TT type OR=0.125(95%CI=0.0141.078).Conclusion:1.The distribution of TAP1-rs1057141A>G gene polymorphism loci inShanxi Han population has no statistical significance，and does not increase the riskof suffering from AITD.2.The frequency distribution of FOXJ1-rs1868823G>T loci gene polymorphismin Shanxi Han AITD patients and healthy controls has statistically significant，individuals who carry GT genotype increase risk of suffering from GD3.632-fold.