Clinical Naoxintong Capsule Qi And Blood Effects On Vascular Endothelial Function In Patients With Angina Pectoris

Objective:To observe the effect of Buchang Naoxintong Capsule in treatment of angina pectoris of coronary heart disease (Qi deficiency and blood stasis) the clinical efficacy and adverse reactions, and to explore its possible mechanism, combined with the treatment of this disease with comprehensive treatment of traditional Chinese medicine and Western medicine for clinical.Methods:A randomized control study,40patients met the inclusion criteria of the qualified subjects were randomly divided into control group (isosorbide mononitrate sustained release tablets combined with aspirin enteric-coated tablets group) combined with traditional Chinese medicine and Western medicine and treatment group (Naoxintong Capsule plus Western medicine group), were treated for14days. The TCM syndrome integral, electrocardiogram, plasma vWF, ET-1, NO etc as the observation items, evaluation of clinical curative effect of the therapy, and to explore the mechanism of. The obtained data accord with normal distribution, using t test and χ2test for the statistical analysis; data does not conform to normal distribution, nonparametric tests were used for statistical analysis.Results:(1)The two groups after the treatment, the plasma vWF (%) values for the treatment group,134.25±31.45,148±16.17in the control group, there was significant difference between two groups (P<0.05);comparison before and after the treatment group, the difference was statistically significant (P<0.05).(2)The two groups after treatment of plasma ET-1(ng/L) value of the treatment group109.28±27.32,130.44±28.27in the control group, there was significant difference between two groups (P<0.05);comparison before and after the treatment group, the difference was statistically significant (P<0.05).(3)Plasma NO treatment, after treatment (umol/L) value was40.78 ±6.12, control group was36.9±7.83, two groups had no significant difference(P>0.05);contrast treatment group,no significant difference (P>0.05).(4)The treatment of ECG total effective rate of treatment group15%, control group10%, two groups had no significant difference (P>0.05).(5)After the treatment of TCM syndrome total score{χ2±S) treatment group was13.5+2.585, control group was22.9±2.79, there was significant difference between two groups (P<0.05); comparison before and after the treatment group, the difference was statistically significant (P<0.05).㈥In the treatment of the two groups had no adverse reactions related to the drug.Conclusion:1conventional treatment of Naoxintong capsule combined with western medicine, can significantly improve the clinical symptoms of angina pectoris of coronary heart disease patients with Qi deficiency and blood stasis, reduce the plasma vWF, ET-1level.2conventional treatment of Naoxintong capsule combined with western medicine on angina pectoris of coronary heart disease, failed to significantly increased plasma NO levels in patients with Qi deficiency and blood stasis type, to improve the ECG efficacy.3Naoxintong capsule is safe, no significant adverse reactions.4The probably mechanism is by reducing vasoconstrictive substance ET-1release, reduce the vascular injury, decrease the release of vWF, thereby protecting the vascular endothelial cell, improve endothelial function, improve the clinical symptoms of the role.