Differentiation Application Of Chinese Medicine Combined With Western Standard Triple Therapy Improve The Clinical Observation Of H. Pylori Eradication Rate

Helicobacter pylori(Helicobacter pylori, Hp) is a gram-negativemicro-aerobic bacteria, the bacteria is so far the only one in the humanstomachdiscovered since1979found that the growing attention of many scholars,the discoverer Warren, Marshall also won the2005Nobel Prize in Physiology and Medicine. Hp with a variety of upper gastrointestinal diseases are closely linked, is one of the independent risk factors of peptic ulcer, plays an important role in the development of chronic gastritis and gastric cancer, gastric lymphoma is closely related wHO will be listed as a causative agent class, according to the statistics, almost all of Hp infection caught will develop gastritis;15%-20%of Hp infection will develop peptic ulcer; Meanwhile,Hp-infected persons incidence of gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma risk compared with the uninfected population increased2-6times; addition, Hp also with unexplained iron deficiency anemia, idiopathic thrombocytopenic purpura, autoimmune gastritis, vitamin B12deficiency, cardiovascular disease, diabetes and cancer and other diseases are closely linked. Western main line currently Hp eradication therapy, second-line therapy, and third-line therapy in several sequential therapy regimen, although western standard triple therapy clearance rate of nearly80%, but its resistance, adverse reactions, poor patient compliance recurrence rate and other issues become more apparent, especially in the context of existing antibiotic abuse, Hp resistance is more obvious than in the past, these problems have prompted clinicians to continuously explore new solutions to improve efficacy, which is the joint application of traditional Chinese medicine dialectical " standard triple therapy" to improve the H. pylori eradication rate provides some clinical basis.Methods:64patients with Hp positive patients met the inclusion criteria, were randomized:Western medicine group (A); western union powder2weeks group (group B); medicine decoction two weeks combined group (group C); decoction of four weeks combined western medicine group (group D), where western union powder for2weeks, combined decoction group and western medicine combined decoction combination of two weeks and four weeks for the medicine group. With the proportion of the sample group and western medicine group was3:1, the sample size of the Medicines1:1:1allocation to determine the sample size in each of the16cases, four groups of64cases. When patients were enrolled on, after the end of treatment and follow-up treatment of the symptoms of Jan. score, the time of enrollment, follow-up after treatment in January PRO scale, SF-36quality of life scores, while the security check such as blood, urine, stool routine, ECG and other vital signs were observed and recorded, the differences between the comparison group. Results:(1) the application of traditional Chinese medicine combined dialectical standard triple therapy alone Hp eradication rate in western standard triple therapy Hp eradication rate of inter-group statistical analysis, suggesting no significant difference (P>0.05);(2) western medicine and Chinese medicine group in group treatment period, symptom scores after treatment compared with pre-treatment symptom scores, showing the difference between the two groups had no significant difference in symptom scores (P>0.05);(3) between the groups before and after treatment PRO there are significant differences in points (P<0.01), and the Chinese Medicines description medicine treatment can improve symptoms in patients before and after treatment of the two groups were statistically analyzed PRO points difference, there are significant differences (P<0.05), and TCM PRO scale scores before and after treatment is greater than the difference between the mean difference between the mean integral medicine group, but there was no significant difference between Chinese medicine group, indicating that Chinese patients symptoms improved self-assessment is more obvious than the western group;(4) of the western medicine group and two groups adverse reactions after treatment statistics found that there are significant differences (P<0.05), described the Medicines reducing adverse drug reactions in terms of improvement compared with western medicine is more obvious.Conclusion:The application of traditional Chinese medicine combined with western dialectical standard triple therapy for Helicobacter pylori (Hp) eradication rate is higher than the simple application of standard triple therapy medicine, traditional Chinese medicine and western medicine group can improve symptoms, the application of traditional Chinese medicine syndrome differentiation combined with standard triple therapy group improved patient symptom score and the comparison group respects quite effective, while reducing patient dropout rate, improve patient compliance, fewer adverse drug reactions are more obvious advantages.