Study On The Effect Of Metal Organic Skeleton Materials On Chiral Separation Of All - Pentyl - β - Cyclodextrin Derivatives

The main works of the thesis were listed as follows:Three capillary columns were prepared for GC, column A containing the chiralMOF, column B containing sodium chloride and peramylated β-cyclodextrins andcolumn C containing chiral MOF and peramylated β-cyclodextrins. Column A andcolumn B were prepared for comparison. The separations for (±)-2-hexanol,(±)-linalool,(±)-citronellal,(±)-methyl-β-hydroxyisobutyrate,(±)-limonene,(±)-roseoxide,(±)-1-cyclohexylethylamine,(±)-isopinocampheol,(±)-dihydrocarvyl acetate,(±)-menthol,(±)-phenylethanol, DL-valine, DL-leucine, α-,β-ionone, linear alkanes,alcohols and Grob test mixtures were studied on three capillary columns.The Co(D-Cam)1/2(bdc)1/2(tmdpy) compound possessing a3-D frameworkcontaining enantiopure building blocks embedded in intrinsically chiral topologicalnets was synthesized to investigate whether the use of chiral MOF can enhanceenantioseparations on a chiral cyclodextrin stationary phase. The experimental resultsindicated that the use of Co(D-Cam)1/2(bdc)1/2(tmdpy) could improve the opticalresolutions.Synthesized left-handed helix metal-organic frameworks material [{Cu(sala)}n],the use of [{Cu(sala)}n] on peramylated β-cyclodextrin could also increase the chiralseparations.We coated the chiral InH(D-C10H14O4)2and peramylated β-cyclodextrins on theinner of capillary column. The InH(D-C10H14O4)2has one left-handed helical ofchains. The enhancing enantioselectivety was obtained on the mixed column ofInH(D-C10H14O4)2and peramylated β-cyclodextrins.