Chiral Separation Of Capillary Electrochromatography Based On Metal - Organic Skeleton Materials

In this dissertation，chiral metal-organic frameworks(MOFs) are utilized as chiralstationary phases for capillary electrochromatography (CEC) separation of racematesand positional isomers．Its main works are summarized as follows：(1) A homochiral helical MOF [Zn2(D-Cam)2(4,4′-bpy)]nwas explored as the chiralstationary phase (CSP) in open tubular capillary electrochromatography (OT-CEC).The MOF coated column has been developed using a simple procedure via MOFspost-coated on the sodium silicate layer. The baseline enantioseparations of flavanoneand praziquantel were achieved on the MOF coated column. The influences of pH,organic modifier content and buffer concentration on separation were investigated.Besides, the separations of positional isomers (nitrophenols and ionone) wereevaluated.(2) Four racemates were successfully separated on a chiral MOF Zn(ISN)2·2H2Ocolumn in OT-CEC. The experimental results showed that Zn(ISN)2·2H2O possessesexcellent recognition ability, the technology of the designed and feasible preparationcolumn is practicable.(3) The fabricated [In3O(obb)3(HCO2)(H2O)]·solvent packed columns showexcellent chiral recognition properties for fast enantioseparation for the CECseparation of (±)-hydrobenzoin,(±)-1-diphenyl-1,2-ethanediol and clenbuterol.Besides, the baseline separations of nitrophenol isomers also were achieved. Whenmixed MOF and spherical silica gel as stationary phase, it further confirms theexcellent chiral recognition properties of MOFs in CEC.