Study On Synthesis, Characterization And Anti-diabetic Activity Of Vanadium Complexes With Small Molecules

The diabetic is caused by a variety of causes, which is metabolic disorder characterized by chronic hyperglycemia. The basic pathology is insufficient in insulin secretion,or has functional defects. At present, Diabetes has become one of the serious diseases threatening human health, and the number of diabetes patients at home and abroad is still increasing year by year. So the prevention and treatment of diabetes are one of the important problems in the field of medicine. The study found that the vanadium compounds have analog insulin physiological function, which can improve diabetes health. However, the study further showed that inorganic vanadium compound has good activity of insulin, It also exists many faults, for instance, it is high toxicity, bad fat-solubility in humans body and big dose of taken. How to design high activity, fewer side effect, analogous activity of insulin vanadium compounds through the choice of ligands has become one of the focus and hotspots in the bioinorganic chemistry research.Two series of vanadium complexes were successfully designed and synthesized after many experiments based on a lot of relevant documents retrieved in this thesis, one is vanadium-hydroxylamido complexes and the other is schiff base compounds. More details as follow:(1) Two series vanadium complexes including seven new schiff base complexes were synthesized. The schiff bases involve salicylaldehyde-3-chloropropylamine, 2-Hydroxy-3-methoxybenzaldehyde-3-Chloropropylamine and 5-chloro-2-hydroxybenzoic acid-2-chloroethylamine; Acetylacetone series include acetylacetonate-glycine schiff base-1,10 o-phenanthroline vanadyl complexes, acetylacetone-alanine schiff base 1,10 o-phenanthroline vanadyl complexes, acetylacetone-glycine schiff base 2,2’-bipyridine vanadyl complexes, acetylacetone-alanine schiff base 2,2’-bipyridine vanadyl complexes. The structure of crystals were determined by the elemental analysis,the IR, and the single crystal diffraction analysis respectively.(2) Three new hydroxylamine vanadium complexes were synthesized. The first ligand is hydroxylamine, and the second ligand is multi-pyridine, including:2,2’-bipyridine (complex external ions are potassium and sodium, respectively) and 1,10-phenanthroline (complex external ion is potassium). Characterization tests were taken for these three kinds of synthetic complexes to determine the structure of the crystal, including elemental analysis, infrared spectrum analysis and X-ray single crystal diffraction.(3) A series of performance tests were taken for these two types of vanadium complexes, including partition coefficient determination and PTP1B inhibitory activity experiments (insulin-like activity test). The preliminary experimental data and conclusion is a basis for further study, especially in the relationship between structure and biological activity of these two vanadium complexes (as insulin-mimetic).