Synthesis And Marine Antifouling Of BIT Derivatives

Benzo[d]isothiazol-3(2H)-one derivatives were widely used in argriculture and medicne health besides efficient, including low toxicity and environmental security.2-(N-arylaminomethyl)-3-oxo-benzo[d]isothiazoles and hydrobenzo[d]-isothiazoleone aliphatic esters were studyed on the marine antifouling performance in this thesis, and designed and synthesised benzo[d]isothiazol-3(2H)-N-heterocyclic acetamides on this basis The relationship between chemical structure and antifouling performance were explored by algal inhibition tests, barnacle biological activities tests, shallow sea hang experiments, and leaching rate tests.2-(N-arylaminomethyl)-3-oxo-benzo[d]isothiazoles had favourable growed inhibitory activities to the marine algas, the better inhibitory activity was on Isochrysis galbana and Platymonas subcordiformis. Barnacle biological activities had shown that the LC50was less than BIT. The toxic effects of electron-withdrawing groups were stronger than the electron-donating groups. As the same substituent group, the toxic effect of ortho-substituent was better than the meta-substituent, also meta-substituent was better than the para-substituent.The hydrobenzo[d]-isothiazoleone aliphatic esters had favourable growing inhibitory activities that the better inhibitory activity was on Isochrysis galbana and Platymonas subcordiformis. It’s shown all compounds has prominent toxic effect on Barnacle biological activities. It’s better toxic effect when the compounds’Substituted had contained less carbon atoms of barnacle larvae. It had good antifouling performance in the seawater for90days. The compounds release rate was determined.Benzo[d]isothiazol-3(2H)-N-heterocyclic acetamides were synthesized, the structures were identified by means of IR,1H NMR. It had found the strongest inhibitory activity was on Isochrysis galbana, the worst on Navicula and the center on Platymonas subcordiformis to inhibition of algaes. It was far less than BIT when the LC50of the compounds were only135μg/L to256μg/L. It shown that introducing heterocyclic groups could effectively enhance the toxic effect of the compounds on the barnacles.