Synthesis Of Cyclic Peptide Nanotubes With Core-shell Structure And Study On Adsorption Properties Of Gases

In this work,4-bromo-o-phenylenediamine and L-type and D-type Boc-Phe-OH are used as raw material. Linear peptides are synthesised by traditional liquid phase synthesis method,and linear peptides and phthaloyl chloride are used as raw material to synthesise cyclic peptide; cyclic peptide nanotubes are self-assembled by purified cyclic peptide structure unit.We used FT-IR, SEM, AFM, TEM and other methods to characterize them.The central core molecule with polyfunctional of π-conjugated structure is completed by the trimerization reaction, functional group protection and deprotection of the reaction process with 3,5-dibromo-acetophenone as starting material.The results show that:a cyclic rotatory hexapeptide and a cyclic octapeptide of the structural unit having different potical are successfully synthesized by liquid phase synthesis method. BET results showed a specific surface area of the L-ring is greater than the D-hexapeptide cyclic hexapeptide.The purified cyclic peptide structure units self-assembled in trifluoroacetic acid (TFA) and deionized water conditions are studied, and found the self-assemble of L-shaped cyclic hexapeptide being faster than D-type, the rate of cyclic octapeptide self-assembly in between;the self-assembling material of aggregating cyclic hexapeptide cyclic peptide 8-D is the mesh with average diameter of 0.90μm; the self-assembling material of cyclic peptide 8-D is webs with average diameter of 0.78μm, comprising a hollow columnar structure.The trimerization reaction to get 1,3,5-tris(3,5-dibromobenzeneyl) benzene with 3,5-dibromo-acetophenone as starting material was synthesised in silicon trachloride as catalyst and ethanol as solution at room temperature.The central core molecule with polyfunctional p-conjugated structure is synthesised by using Pb/Cu catalyst systems Sonogashira coupling reaction and methanol/tetrahydrofuran/deprotection systems.