The Relationship Between The Distribution Of IgA, IgG And IgM Secreting-cells In The Gastrointestinal Tract And Ages In Rabbits

Digestive tract mucosa is not only the first line of defense against infection, but also one of the most vulnerable parts of infection. Therefore, the study of the intestinal mucosal immune system is very important to control the immune system. Immunoglobulin (immunoglobulin, Ig) is a class of special proteins produced by specific plasma cells stimulated by antigens, which can induce the occurrence of humoral immunity, that is, the antibody (antibody, Ab). At present, there are other animal immunoglobulin secreting-cells in the digestive tract mucosa, but rabbits as a common economic animal, experimental animals, but rarely reported. In order to clarify the relationship between the distribution of IgA, IgG and IgM secreting-cells in the gastrointestinal tract and ages in rabbits, the analysis of the stomach, small intestine and large intestine of different age groups were observed and analyzed by the methods of anatomy, immunohistochemistry and cell number statistics and analysis.Results show that in different age groups, IgA, IgG and IgM seereting-eells were distributed mainly in the mucosa lamina or near the glands in the gastrointestinal tract (stomach, small intestine, large intestine), but there are differences in the main settlements in different parts. With the growth of the age, these cells showed the first increase and then decreased. The distribution density of the youth group was greater than that of the other two age groups. Three kinds of immunoglobulin secreting-cells were found in the entire gastrointestinal tract. The distribution density of the cells in the pylorus is greater than that in the fundus, the distribution density of the cells in the duodenum is the most abundant, and in the large intestine, the number of the target cells in the appendix is the largest. From the whole point of view, the distribution density of all parts of the three age groups were basically followed the rule of first increasing and then decreasing, reaching the maximum at the duodenum. Worthy of note is that the number of Ig-secreting-cells in the appendix, which with rabbit appendix as specialized immune structure consistent. In addition, there were differences between the number of he three types of B cells, the number of IgA secreting-cells was slightly more than the another two types, and the number of IgG and IgM secreting-cells were not quite different.In summary, abundant IgA, IgG and IgM secreting-cells were distributed throughout the gastrointestinal tract mucosa, the pylorus and duodenum are the main parts of the intestinal mucosal immune function of the digestive tract, the appendix is immune to structural specialization, also plays an important role in immunity. By the change of cells’distribution density with age, it can be concluded that the ability of young group to resist pathogen invasion was stronger than that of juvenile arid elderly groups. This provides a strong basis for the study of the strong role of the digestive tract in the local and systemic mucosal immune response.