The Expressionand Correlation Of NF-κB And Survivin In Stomach Cancer

BackgroundsThe stomach cancer is one of higher mankind’s death rate malignant tumors, the rateof the outbreak has to descend, but still threatens mankind health in recent years. Theoccurrence of the stomach cancer relates to development and various factors, like region,age and HP infection etc., but the concrete mechanism of its occurrence hasn’t clarified.The NF-κB is a kind of pit in the body to transcribe factor, the ability and many genesstarts sub-district after activating of fixed pit Mao the sour sequence combine but startgene to transcribe and participate in various paroxysms outbreak process, it not only andpropagating of cell, Diao Wu, growth, divide, the immunity of cell period and machinebody should answer status relevant, and return and various occurrence of stomach andintestines tumors and gradually transfer related. The research expresses that examines itsexpression level to show Zhao to heat up in the stomach cancer organization, and confirmthat the NF-κB that activate can influence propagating of tumor cell and Diao Wu.AndSurvivin is the new member of IAP household, can develop a different function of anti-Diao Wu especially, the Survivin high expression causes the Diao Wu repress to mayhave an important function in the occurrence development of stomach cancer in thestomach cancer organization, and also with the occurrence of the stomach cancer andgradually transfer to have to show Zhao relativity. The same research expresses that theNF-κB leads in the examination masculine gender in the stomach cancer higher, and itwith Survivin express to present relativity in the stomach cancer, two it of the relativityhave the stomach cancer Ba to hope to become future to cure of new research order, buttwo expression and still Be treated to a further research at the stomach cancer nascent andconcrete relativity. Objective1. It is beside to understand stomach cancer organization and normal cancer theexpression circumstance of NF-κB and Survivin in the organization2. Compare NF-κB and Survivin organize the relativity that medium expression andpopulation learn an of factor and the cancer cooking stove growth part and tumor size inthe stomach cancer.3. Explicit NF-κB and Survivin organize in the relativity of expression in thestomach cancer.4. Explicit NF-κB and Survivin organize in the stomach cancer whether the mediumexpression and organization credit type, lymphoid knot transfers, the TNM cent expect tobe related.5. System and comprehensive analyze the correlation of the NF-κB and thecorrelation between Survivin and stomach cancer and the NF-κB and Survivin.Methods1. The selection postpones Yanan university affiliated hospital May,2012and May,2013the surgical operation cut off of stomach cancer organization paraffin waxspecimen is50, normal cancer side organization paraffin wax specimen20.2. The specimen that will make selection checks a case juniors aged age, the set ofsex and cents, such as stomach cancer part and tumor size. etc.3. The stomach cancer organization that will make selection presses to organize acredit type, have have no the lymphoid knot transfer, the TNM cent expect respectively acent set. Make selection specimen juniors to go a pathologic slice back up.4. Applied the immunity set turn SABC method to have the good pathologic slicecarry on dyeing, respectively under the microscope observation and record50stomachcancer organizations and20normal cancers beside in the middle of the organization theexpression circumstance of NF-κB and Survivin, and carry on relativity analysis.5. The statistics learns a processing: All experiment datas are learned with theSPSS17.0statistics the software carries on statistics to learn analysis to the result andcount a data adoption χ2examination, two change to measure of the adoption Spearmangrade is related to analyze, P<0.05for have statistics to learn meaning.Results1. The NF-κB organizes a medium male expression to lead to74%in the stomachcancer and organize in the normal cancer side in of the male expression lead to15%andorganize a medium expression rate in the stomach cancer is more obviously high than a normal cancer to organize beside, P <0.05, two the difference have statistics to learnmeaning. Survivin organizes a medium male expression to lead to82%in the stomachcancer and organize in the normal cancer side in of the male expression lead to5%, P<0.05, two difference includes statistics to learn meaning. Past NF-κB and Survivinorganize in the stomach cancer in all present high expression trend.2. NF-κB and Survivin at sufferer over55years of age and55years old theexpression difference of the masculine gender in the sufferer as follows have statistics tolearn meaning(P <0.05), past NF-κB and Survivin organize the age difference of mediumexpression and stomach cancer sufferer to contain obvious relativity in the stomachcancer. NF-κB and Survivin is having no obvious difference(P>0.05) by the maleexpression in the sex cent set, NF-κB and Survivin organize medium expression and thesufferer’s sex in the stomach cancer have no obvious relativity. And in the cancercooking stove growth part cent set, the male expression of the NF-κB and Survivin alsowithout the obvious difference(P>0.05), past two of the growth part of expression andcancer cooking stove also have no obvious relativity. NF-κB and Survivin at is biggerthan a5cm set moderate is smaller than a male expression in set of5cm of the differencehave a statistics to learn meaning(P <0.05), past two of the masculine gender expressionand tumor of the size present relativity.3. Organize in the stomach cancer is together all male expression in the Survivin andNF-κB of is18, together all is feminine gender expression of is2, examine stomachcancer organization in two of relativity, can use a double to have no preface classificationdata of connection examination. Take α=0.05Be examine level, X2is5.53, P <0.05,connection coefficient C=0.315, the C value generally takes0-1of, express NF-κ B andSurvivin’s organizing in the stomach cancer medium expression is related, and presentspositive relativity.4. Organize at the stomach cancer made selection in, NF-κB and the expression ofSurvivin and the histology type of the stomach cancer with have have no the lymphoidknot transfer have no obviously related, the difference has no statistics learnmeaning.NF-κB and Survivin organize medium expression and the TNM cent of stomachcancer to expect in the stomach cancer closely related, P <0.05, the difference all has astatistics to learn meaningConclusion1. The NF-κB organizes in the stomach cancer in present high expression trend, andand sex difference and cancer cooking stove of the organization credit type and sufferer of stomach cancer grow part and have have no the lymphoid knot transfer have noobviously related, but expect with size and TNM cent of the sufferer’s age, tumorobviously related, express NF-κ B and taking place of stomach cancer and prepare afterhave obvious relativity2. Survivin organizes in the stomach cancer in also present high expression trend,grow the organization credit of part and stomach cancer with the stomach cancersufferer’s sex difference and cancer cooking stove type and have have no the lymphoidknot transfer have no obvious relativity, and size and TNM cent of the sufferer’s age,tumor expect to be related and express Survivin also with taking place of stomach cancerand prepare after have already shown Zhao relativity.3. Learn analysis through the statistics and it combines it organizes in the stomachcancer in expression of relativity, NF-κB and Survivin organize a medium expression topresent positive relativity in the stomach cancer, two be in conjunction with theoccurrence and development of promoting the stomach cancer.4. This research provides a theory toward the treatment for the gene Ba of stomachcancer on the foundation of occurrence development mechanism of member level explicitstomach cancer basis.