| ObjectiveThe aim of this study was to explore the role of different nutrient intake onhormone level changes of GH/IGF-1axis and early postnatal growth and developmentof very low birth weight premature infants (VLBWI).MethodsA total of62cases of weights appropriate for gestational age (AGA) ofpremature VLBWI were collected, who were feed in accordance with ESPGAN2010premature infants nutrition guidelines as soon as they born. Then according todifferent individual average daily protein and calorie intake within28days, all thecases were divided into three groups. There are low protein low calorie group (groupA,29cases), high protein low calorie group (group B,24cases) and high protein highcalorie group (group C,9cases). Various growth parameters of the three groups weremonitored during different ages (d0, d7, d14and d28of life) which including bodyweight (BW), body length (BL), head circumference (HC), body mass index (BMI),weight SD, length SD, head circumference SD and average daily weight gain rate(WG). At the same time, applying respectively chemiluminescence immunoassay andradiommunoassay to detect the serum levels of growth hormone (GH), insulin-likegrowth factor I (IGF-I) and insulin-like growth factor binding protein3(IGFBP-3) inthe corresponding day, and calculate IGF-1/IGFBP-3molar ratio.Results1. Three groups’ various growth parameters (BW, BL, HC, BMI, WG, IGF-1,IGFBP-3, IGF-1/IGFBP-3) grew along with the age after birth（P﹤0.05或P﹤0.01）.The weight SD, length SD, head circumference SD in those three groups decreasedalong with the age after birth（P﹤0.001）. All three groups’ GH levels had decreased with age after birth（P﹤0.01）.2. Except the first postnatal7d, GH level of group B was lower than group A(p﹤0.001), there was no significant difference between the two groups in the other timepoints(d0, d14and d28after birth). There was no significant difference of variousgrowth parameters (BW, BL, BMI, WG, weight SD, length SD, head circumferenceSD, IGF-1/IGFBP-3) between group B and group A, and the same phenomenon canbe seen with HC, IGF-1, IGFBP-3levels at each time point after birth(d0, d7, d14andd28after birth).3. The BW of group C was higher than group A(p﹤0.05). HC of group C in d7,IGF-1of group C in d14, as well as HC, IGF-1and IGFBP-3of group C in d28wereall higher than that of group A(p﹤0.05), while other growth parameters of group Chad no significant difference with group A which including BL, BMI, WG, weight SD,length SD, head circumference SD, IGF-1/IGFBP-3. There was also no significantdifference of GH levels between group C and group A at each time point after birth(d0,d7, d14and d28after birth).4. IGFBP-3of group C in d7, IGF-1of group C in d14, as well as IGF-1andIGFBP-3of group C in d28were all higher than that of group B(p﹤0.05or p﹤0.01).But other growth parameters of group C had no significant difference with group Bwhich including BW, BL, BMI, WG, weight SD, length SD, head circumference SD,IGF-1/IGFBP-3. There was also no significant difference of HC and GH levelsbetween group C and group B at each time point after birth(d0, d7, d14and d28afterbirth).Conclusions1. Increasing nutrition intakes can improve the secretion levels of GH/IGF-1axis-related hormones;2. Nutrition and GH/IGF-1axis had the role of regulation to the early growth anddevelopment of preterm VLBWI. ObjectiveThe aim of this study was to explore the role of different levels of GH/IGF-1axison early postnatal growth and development of very low birth weight premature infants(VLBWI).MethodsVarious growth parameters of premature VLBWI were monitored duringdifferent ages(d0, d7, d14and d28) which including body weight (BW), body length(BL), head circumference (HC), weight SD, length SD, head circumference SD, bodymass index (BMI) and average daily weight gain rate (WG). At the same time,applying respectively chemiluminescence immunoassay and radiommunoassay todetect the serum levels of growth hormone (GH), insulin-like growth factor I (IGF-I)and insulin-like growth factor binding protein3(IGFBP-3) in the corresponding day,and calculate IGF-1/IGFBP-3molar ratio.24cases of premature VLBWI had thesame nutritional intake(including protein and caloric intake). According to individualserum IGF-1levels in d28after birth, all of the cases were divided into the low levelgroup(group LL, n=12) and the high level group(group HL, n=12).Results1. Two groups’ growth parameter index(including BW, BL, HC, BMI and WG)showed an upward trend after birth, and the BW level amd WG level of LL groupbelow those of HL group(P＜0.05), while the BL, HC, BMI level differences betweenthe two groups had no statistical significance.2. Two groups’ weight SD, length SD, head circumference SD and△weight SDlevels showed negative growth trend after birth. There was no statistical significancebetween the two groups in weight SD, length SD and head circumference SD level differences, but the weight SD level of LL group were higher than that of HL group(P＜0.05).3. Two groups’ GH and IGFBP-3levels had no significant differences changewith age after birth. And there was also no statistical significance of those hormonelevel differences between the two groups at the same time points.4. There was no significant difference change with age after birth in the IGF-1level and IGF-1/IGFBP-3level of LL group, but an uptrend after birth in HL group.The IGF-1、IGF-1/IGFBP-3levels of LL group below those of HL group(P＜0.05).Conclusions1. IGF-1play a major regulation role for early growth and development ofpremature VLBWI.2. The early growth and development of premature VLBWI may not depend onGH. ObjectiveThe aim of this study was to explore the relationship between GH/IGF-1axis andearly postnatal growth and development of very low birth weight premature infants(VLBWI) with different intrauterine growth situation.MethodsAccording to individual gestational age and birth weight,32cases of prematureVLBWI were divided into the small for gestational age (SGA) group and theappropriate for gestational age (AGA) group. After birth, all the cases were given thesame nutritional intake (including protein and calorie intakes) during the observationtime, and monitored the growth parameters of the two groups during different ages(d0, d7, d14and d28of life) which including body weight (BW), body length (BL),head circumference (HC), body mass index (BMI), weight SD, length SD, headcircumference SD and average daily weight gain rate (WG). At the same time,applying respectively chemiluminescence immunoassay and radiommunoassay todetect the serum levels of GH, IGF-I and IGFBP-3in the corresponding day, andcalculate IGF-1/IGFBP-3molar ratio.Results1. The gestational age of SGA group was greater than AGA group (p <0.001).Two groups’ various growth parameters (BW, BL, HC, BMI and WG) had significantdifference between the different time points (p <0.001), grew along with the age afterbirth. But there was no statistically significant difference of those growth parametersbetween the two groups.2. The weight SD and length SD after birth in both groups had the negative trend(p<0.001), while no difference between the different time points after birth in head circumference SD. The weight SD, length SD and head circumference SD of SGAgroup were lower than those of AGA group (p<0.001).3. The GH levels from both groups were highest at birth, and decreasedgradually after birth (p<0.01). There was no significant difference between the twogroups at the same time point except that d7GH level of SGA group were higher thanAGA group(p <0.05).4. The two groups had an upward trend of IGF-1level and IGFBP-3level afterbirth(p <0.01), and the total IGF-1level, IGF-1and IGFBP-3level in d28of SGAgroup were lower than those of AGA group(p <0.05). There was no significantdifference of IGF-1/IGFBP-3level from the two groups change with age after birth,and also no statistically significant difference between the two groups.Conclusions1. Serum IGF-1and IGFBP-3levels in SGA group were lower than that of AGAgroup on premature VLBWI.2. Low levels of IGF-1and IGFBP-3may result in growth retardation. |
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